The maternal-to-zygotic transition in #zebrafish is activated by TFs that open #chromatin via enhancers lacking H3K4me2. @MTLeeLab &co identify a parallel pathway that is activated by #enhancers that bear H3K4me2, showing that both act in combination @PLOSBiology https://plos.io/3IFqYMc
#chromatin
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https://www.europesays.com/us/21397/ Discovery of a genetic dimmer switch controlling embryonic development #Cell #Chromatin #dna #Embryo #Gene #GeneExpression #genes #genetic #Genetics #Genome #genomics #laboratory #MedicalResearch #research #Science #UnitedStates #UnitedStates #US
Epigenetic regulators like EZH2 are mutated in #Bcell #lymphoma, but what is their effect? This study reveals a role for mutant EZH2 in lymphomagenesis, using a new method for measuring #epigenetic heterogeneity & intra- #chromatin connectivity in #cancer @PLOSBiology https://plos.io/4mZcS8n
How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
I am very happy to announce that our work on hemichordate gene expression and chromatin accessibility dynamics is now published on Nature Ecology and Evolution! https://www.nature.com/articles/s41559-024-02562-x
One of these black-eyed Susan blooms is not like the others, and may be thinking “I have a feeling I forgot to unpack 
something!” #bloomscrolling #chromatin #DNA #aurones #epigenetics
CFDP1 regulates cell proliferation & higher-order #chromatin structure. This study shows that CFDP1 is essential for structural stability of centromeric #heterochromatin, so influencing #microtubule nucleation during #MitoticSpindle formation #PLOSBiology https://plos.io/3W5eFhc
#Wolbachia causes embryonic lethality in #FruitFlies by modifying #chromatin integrity in sperm. @KaurTweets @Symbionticism &co show that this occurs in the wMel-transinfected #Aedesaegypti #mosquitoes used to control vector-borne diseases #PLOSBiology https://plos.io/3xgOsBH
The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://plos.io/3oZTkHP
On this #ThrowbackThursday I want to go back to our Episode of last week. It was our Episode 
! On to the next 100. #chromatin #epigenetics #podcast
You can find all 100 Episodes here: https://www.activemotif.com/podcasts
in a study published March 23 in Nature Microbiology, Li and colleagues reveal how the #virus responsible for #COVID19 remodels #chromatin, the complex of #DNA and #proteins that makes up #chromosomes. The resulting changes in #geneexpression may be responsible for the #immune #dysregulation seen in #infected people and may offer clues as to why some experience #prolonged #symptoms. #LongCovid https://www.the-scientist.com/news-opinion/covid-19-infections-may-reshape-genetic-landscape-71045
The Scientist Magazine®COVID-19 Infections May Reshape Genetic LandscapeSARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests.
Excitement!
Our new research article reveals a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates #nuclear architecture, #chromatin organisation and #gene expression.
https://doi.org/10.1038/s41467-023-37021-x
#AcademicChatter #AcademicMastodon #Mechanobiology #CellBiology #Lab #Publishing #OpenAccess #TeamScience
From: @thebyronlab
https://fediscience.org/@thebyronlab/110078432577027657
Replied in thread
Re-posting an #introduction after moving server:
My research group at the Wellcome Centre for Human Genetics in Oxford uses #SingleCell techniques and Genome Architecture Mapping to study #epigenetics #Chromatin and #GenomeFolding in rare #NeurodevelopmentalDisorders.
I (He/Him) love to be outside #Hiking or #Cycling and I’m a big fan of #FlightFree travel. Interested in #Equity issues in STEM, trying to read and educate myself to be a better ally.
Toot at me with your #Andor theories!
#Introductions
I just moved my account from qoto.org to mastodon.nl. Nothing against the fine folks at Qoto, just a more recognizable address.
My interests are in:
- Epigenetic regulation of stem cells and lineage commitment
- Single cell omics and lineage trajectories of embryonic and heart development
- Gene-regulatory networks of development and differentiation
www.veenstralab.nlVeenstra LabResearch of development and differentiation