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PLOS BiologyThe antiviral cytokine interferon is thought to act through the induction of hundreds of genes. In this <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> Perspective, <a href="https://bird.makeup/users/jschoggins" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@jschoggins</a> highlights recent findings that instead suggest distinct viruses are targeted by small subsets of the induced gene repertoire. <a href="https://plos.io/4m7hOYi" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4m7hOYi</a>

PLOS BiologyIn this <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> Consensus View, <a href="https://bird.makeup/users/neurofishh" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@neurofishh</a> <a href="https://bird.makeup/users/corbolab" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@corbolab</a> &co propose a new, consolidated, pan-vertebrate naming system for the rod and cone photoreceptors of the eye. <a href="https://plos.io/4m4QcTC" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4m4QcTC</a>

CharrveinContrary to ... expectations, evolution experiments with microbes recurrently show that the early stages of adaptation often proceed via large-effect, highly pleiotropic mutations [4,5].Cool paper <a href="https://mastodon.online/tags/plos" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plos</a> <a href="https://mastodon.online/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://mastodon.online/tags/regevolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#regevolution</a> <a href="https://mastodon.online/tags/pleiotropy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pleiotropy</a> <a href="https://mastodon.online/tags/nettwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nettwork</a> evolution <a href="Https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002922" rel="nofollow noopener noreferrer" translate="no" target="_blank">Https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002922</a>

PLOS BiologyVaccines are one of the greatest scientific success stories of our time. They have saved more than 154 million lives in the last 50 years — more than 1 life every 10 seconds.Recent moves to strip funding from vaccine-related research are shortsighted and self-harming. As is the use of precious resources to revisit debunked claims of links to autism.The best vaccine isn’t useful if it is not distributed, or not socially accepted. Vaccine equity and hesitancy remain great challenges. Globalizing antivaccine activism could become our greatest hurdle.It is not time to defund, but rather invest in vaccines.Read our latest editorial in <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a>: Vaccines work… and do not cause autism <a href="https://fediscience.org/tags/vaccines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vaccines</a> <a href="https://fediscience.org/tags/vaccination" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vaccination</a> <a href="https://fediscience.org/tags/immunization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunization</a> <a href="https://fediscience.org/tags/WorldImmunizationWeek" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#WorldImmunizationWeek</a> <a href="https://fediscience.org/tags/measles" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#measles</a> <a href="https://fediscience.org/tags/outbreak" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#outbreak</a> <a href="https://fediscience.org/tags/vaccinehesitancy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vaccinehesitancy</a><a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003143" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003143</a>

PLOS BiologyHow does the lysogenic-lytic cycle work in intestinal <a href="https://fediscience.org/tags/bacteriophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteriophages</a>? <a href="https://mstdn.science/@dbikard" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@dbikard</a> &co show that hankyphage produces defective viral particles & identify RepCHP as master repressor of this <a href="https://fediscience.org/tags/phage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#phage</a>'s lytic cycle <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/41Rr22S" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/41Rr22S</a>

PLOS BiologyHow does sensory information construct representations in the human brain? This study shows that a network including prefrontal & posterior <a href="https://fediscience.org/tags/ParietalCortex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ParietalCortex</a> & anterior <a href="https://fediscience.org/tags/insula" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#insula</a> has a key role in translating perceptual information to concepts, semantics & action plans <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4lbXN2b" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4lbXN2b</a>

PLOS BiologySleep regulation in <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a>. <a href="https://drosophila.social/@dissel_lab1" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@dissel_lab1</a> &co show that <a href="https://fediscience.org/tags/cholinergic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cholinergic</a> <a href="https://fediscience.org/tags/neurons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neurons</a> in the dorsal fan-shaped body (dFB) play a major role in <a href="https://fediscience.org/tags/sleep" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sleep</a> modulation in this neurochemically heterogeneous region of the fly brain <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/42uPczp" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/42uPczp</a>

PLOS BiologyHow do worms navigate based on learned experience? <a href="https://neuromatch.social/@AndrewLeifer" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@AndrewLeifer</a> &co reveal flexible behavioral strategies & distributed neural computations underlying learning-dependent odor <a href="https://fediscience.org/tags/navigation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#navigation</a> in <a href="https://fediscience.org/tags/Celegans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Celegans</a> <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4bYZs7c" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4bYZs7c</a>

PLOS BiologySleep can support <a href="https://fediscience.org/tags/memory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#memory</a>, but can memory hyperfunction cause <a href="https://fediscience.org/tags/sleep" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sleep</a> deficits? They find that the short-sleep <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> mutant "<a href="https://fediscience.org/tags/insomniac" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#insomniac</a>" has enhanced memory and that PKA signaling balances sleep & memory in these flies <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4ihHNtL" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4ihHNtL</a>

PLOS BiologyThe Shh pathway is a key regulator of feather development. <a href="https://bird.makeup/users/rorylcooper" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@rorylcooper</a> & <a href="https://bird.makeup/users/lanevol" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@lanevol</a> show that inhibiting Shh during chick embryogenesis results in unbranched <a href="https://fediscience.org/tags/feather" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#feather</a> buds, similar to those seen in some of their <a href="https://fediscience.org/tags/dinosaur" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dinosaur</a> ancestors <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4bIYQCx" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4bIYQCx</a>

PLOS BiologyAnalysis of <a href="https://fediscience.org/tags/IUCNRedList" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IUCNRedList</a> data on 67,217 animal species reveals that a range of <a href="https://fediscience.org/tags/conservation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#conservation</a> actions successfully conserved species at greatest risk of extinction, but rarely resulted in full recovery <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3XUzEDd" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3XUzEDd</a>

PLOS BiologySecretion mechanisms of many T6SS effectors in Gram-neg <a href="https://fediscience.org/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteria</a> remain unclear. <a href="https://genomic.social/@DrDorSalomon" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@DrDorSalomon</a> &co identify a new class of <a href="https://fediscience.org/tags/T6SS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#T6SS</a> effectors, which can harbor either 1 or 2 toxic domains and use the WHIX domain as a secretion motif <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4iCxVL3" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4iCxVL3</a>

PLOS BiologyBright colors observed across the animal world are often used during mate choice. <a href="https://ecoevo.social/@dickmerrill" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@dickmerrill</a> explores a <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> study of genetic & neural mechanisms contributing to evolution of visual mating decisions in Heliconius butterflies. Paper: <a href="https://plos.io/4iHQDRd" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4iHQDRd</a> Primer: <a href="https://plos.io/4ipW7QS" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4ipW7QS</a>

PLOS BiologyCurrent methods for profiling <a href="https://fediscience.org/tags/HistoneModifications" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HistoneModifications</a> require cell isolation & don't work with all tissue types. <a href="https://bird.makeup/users/jellevda" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@jellevda</a> &co adapt Targeted DamID (TaDa) to profile cell-type-specific <a href="https://fediscience.org/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> marks throughout the genome, in vivo, without cell isolation <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3Dw8sUD" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3Dw8sUD</a>

PLOS BiologyNeural circuits that link genetic variation to <a href="https://fediscience.org/tags/behavior" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#behavior</a>: This study of mate choice behavior in Heliconius cydno <a href="https://fediscience.org/tags/butterflies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#butterflies</a> shows that alterations to the peripheral nervous system, driven by genetic & gene expression differences, can alter essential behaviors <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4iHQDRd" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4iHQDRd</a>

PLOS BiologyA role for translational control in stem & differentiating cells. This study shows that signals from the <a href="https://fediscience.org/tags/StemCell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#StemCell</a> niche induce changes in translational rates (via eIF3d1 phosphorylation) to control stem cell fate in <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> testis <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3Dw1W07" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3Dw1W07</a>

PLOS BiologyBacterial ABC peptide transporters are involved in processes like nutrient uptake. This study solves <a href="https://fediscience.org/tags/cryoEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cryoEM</a> structures of the <a href="https://fediscience.org/tags/Ecoli" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Ecoli</a> dipeptide <a href="https://fediscience.org/tags/transporter" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transporter</a> DppABCDF in both apo & ATP analog-bound forms, providing insights into assembly & import mechanism <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3DxP8pU" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3DxP8pU</a>

PLOS BiologyIntercellular interactions between DIP & Dpr proteins coordinate <a href="https://fediscience.org/tags/NeuralNetwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NeuralNetwork</a> assembly in flies, but what if they're expressed in the same cell? This study shows that DIPs & Dprs can interact in cis, & that the cis/trans balance plays a role in neural development <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3XpRs9f" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3XpRs9f</a>

PLOS Biology<a href="https://fediscience.org/tags/Sorghum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Sorghum</a> develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. <a href="https://bird.makeup/users/jeanmichelane" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@jeanmichelane</a> &co show that diazotrophic <a href="https://fediscience.org/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteria</a> in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3EYPZjK" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3EYPZjK</a>

PLOS BiologyDynamics of a supergene. A study of the BC supergene in wing color morphs of the African monarch <a href="https://fediscience.org/tags/butterfly" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#butterfly</a> by <a href="https://ecoevo.social/@rishidekayne" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@rishidekayne</a> &co reveals dynamic evolution of <a href="https://fediscience.org/tags/supergene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#supergene</a> haplotypes, fueled by incomplete recombination suppression <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3DiFhnL" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3DiFhnL</a>

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