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#tau

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What is known as the #prodromal phase, the years when #Alzheimer's is attacking the brain but the clinical presentations may not yet be apparent. "One early hallmark is that sticky protein called beta-amyloid, which over time builds up into brain-clogging #plaques. #Amyloid alone isn’t enough to damage memory — plenty of healthy people’s brains harbor a lot of plaque. An abnormal #tau protein that forms neuron-killing tangles is one of several co-conspirators."

yahoo.com/news/silent-brain-ch

Why diagnose someone with #Alzheimer's who has no memory issues but a build-up of #tau and/or #amyloid protein? Here's why. In a Nov, call with Wall St. analysts, Masoud Toloue, the chief executive at Quanterix, pointed out that the company’s blood test for tau — p-Tau 217 — had been recommended by the panel for diagnosing the disease. “We believe we’re in a strong position to capitalize on these opportunities,” Toloue said. "Opportunities"? Sickening.

latimes.com/science/story/2024

Los Angeles Times · The plan to diagnose Alzheimer’s in people with no memory problems By Melody Petersen

Several progressive #neurodegenerative disorders, including #Alzheimer’s disease, are defined by having #tau #proteins in the #brain. Researchers are seeking to identify the mechanisms behind these tau proteins to develop treatments, however, their efforts to detect biomarkers in blood has been hampered by the protective blood-brain barrier.
#Engineering #Biology #Neuroscience #Medical #sflorg
sflorg.com/2023/01/eng01312301

www.sflorg.comFocused ultrasound mediated liquid biopsy in a tauopathy mouse modelThe method, known as sonobiopsy, uses focused ultrasound to target a precise location in the brain.