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#amyloid

1 post1 participant0 posts today
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DrBob, Neurologist, 🧠Mechanic

Do we have #Alzheimer’s disease all wrong?

“As Science noted in its story on the retracted paper, scientists are still debating whether the #amyloid theory is viable. The skeptics cite the fraudulent research and lack of a genuine breakthrough; supporters can point to this new class of drugs including #donanemab that have led to some improvement in some patients.”

vox.com/future-perfect/355108/

Public
(((Cindy Weinstein)))

Honored to keep company with #neurologist, #DanielGibbs's #book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.

If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.

Frequently bought together: Finding the Right Words, A Story of Literature, Grief, and the Brain ($19.84) by Cindy Weinstein with Bruce Miller, MD, and A Tattoo on my Brain: A Neurologist's Personal Battle Against Alzheimer's Disease ($24.95) by Daniel Gibbs, MD with Teresa H. Barker.
Public
(((Cindy Weinstein)))

Honored to keep company with #neurologist, #DanielGibbs's book about his own experience of #dementia. The tattoo in the title is the #brain bleed (aka #ARIA) that occurred while in #clinicaltrials related to anti-#amyloid drugs. He has no regrets & would do it all over again if it might advance brain science & help in the effort to #ENDALZ.

If you have read either my #memoir or his, please consider reviewing them on #amazon. In different ways, we both aim to inform readers & undercut #stigma.

Public
(((Cindy Weinstein)))

What is known as the #prodromal phase, the years when #Alzheimer's is attacking the brain but the clinical presentations may not yet be apparent. "One early hallmark is that sticky protein called beta-amyloid, which over time builds up into brain-clogging #plaques. #Amyloid alone isn’t enough to damage memory — plenty of healthy people’s brains harbor a lot of plaque. An abnormal #tau protein that forms neuron-killing tangles is one of several co-conspirators."

yahoo.com/news/silent-brain-ch

#EndAlz
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(((Cindy Weinstein)))

Why diagnose someone with #Alzheimer's who has no memory issues but a build-up of #tau and/or #amyloid protein? Here's why. In a Nov, call with Wall St. analysts, Masoud Toloue, the chief executive at Quanterix, pointed out that the company’s blood test for tau — p-Tau 217 — had been recommended by the panel for diagnosing the disease. “We believe we’re in a strong position to capitalize on these opportunities,” Toloue said. "Opportunities"? Sickening.

latimes.com/science/story/2024

Los Angeles Times · The plan to diagnose Alzheimer’s in people with no memory problems By Melody Petersen
#EndAlz
Replied in thread
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(((Cindy Weinstein)))

@wlf_warren. You are welcome. You can access them yourself -- there is one of misfolded #proteins; another with #tau and #amyloid stains -- (and some other photos from the wayback machine) at the book website. The book itself has the images in black and white, but the website has them in color. Just click this link and then go to the book link and then click the figures link! weinsteinandmiller.com

Finding the Right WordsFinding the Right Words by Cindy Weinstein and Dr. Bruce MillerFinding the Right Words is an invaluable guide for families dealing with a life-changing diagnosis. In chapters of profound and sometimes humorous remembrance, Weinstein relies on literature to describe the shock of her father's diagnosis and his loss of language and identity. Writing in response to Weinstein's deeply personal narrative, Dr. Miller describes the neurological processes responsible for the symptoms displayed by her father.
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DrBob, Neurologist, 🧠Mechanic

Disease Modifying Therapy for #Alzheimer's #Dementia

"The long-awaited era of disease-modifying therapy for Alzheimer’s disease has finally arrived and will substantially impact how the disease is perceived and managed. The drugs closest to widespread clinical implementation are #lecanemab and #donanemab—intravenous #MonoclonalAntibodies that remove β #amyloid plaques from the #brain and can slow cognitive and functional decline."
#leqembi
cnmri.com/2023/07/21/disease-m

Chart comparing Lecanemab vs Donanemab
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