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#sideeffects

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The claim is circulating that antidepressants can cause overheating and dehydration. This is a genuine public health message, but it's not so simple: diuretics, beta blockers, ACE inhibitors, antipsychotics, and some antihistamines may also interact badly with hot weather.
nytimes.com/2024/06/15/well/li (excerpt in a reply)

There's even doubt about antidepressants having this effect. A recent paper in eClinicalMedicine looked at all the studies they could find and concluded that there wasn't evidence of antidepressants causing overheating in hot weather - though some other medicines do.

"Current evidence supports strong anticholinergics, non-selective beta-blockers, adrenaline, and anti-Parkinson’s agents impairing thermoregulation during heat stress ... physicians should interpret with caution conventional public health messaging related to the thermoregulatory effects of some drugs (e.g., antidepressants) during hot weather."
thelancet.com/journals/eclinm/

The New York Times · These Common Medications Can Make Heat Waves More DangerousBy Katie Mogg

Hair loss drug finasteride can cause debilitating side-effects, men say
For decades, millions of men around the world have turned to a drug — finasteride, or Propecia, its most well-known brand name — to slow hair loss. But an increasing number of experts are sounding the alarm that this medication can cause rare but serious side-effects, which can persist after stop...
#health #medicine #sideeffects #News
cbc.ca/news/health/hair-loss-d

How to select relevant items for monitoring? Case example of a pragmatic process for mapping immune checkpoint inhibitor #SideEffects to items from existing item libraries ( #CTCAE #EORTC #FACIT )
jpro.springeropen.com/articles

SpringerOpenMapping immune checkpoint inhibitor side effects to item libraries for use in real-time side effect monitoring systems - Journal of Patient-Reported OutcomesBackground Monitoring for the side effects of novel therapies using patient-reported outcomes (PROs) is critical for ensuring patient safety. Existing static patient-reported outcome measures may not provide adequate coverage of novel side effects. Item libraries provide a flexible approach to monitoring for side effects using customized item lists, but the ideal process for matching side effects to items sourced from multiple item libraries is yet to be established. We sought to develop a pragmatic process for mapping side effects to items from three major item libraries using immune checkpoint inhibitor (ICI) side effects as an example. Methods Using a consumer- and clinician-driven list of 36 ICI side effects, two authors independently mapped side effects to Common Terminology Criteria for Adverse Event (CTCAE) terms, and then to three item libraries: the Patient-Reported Outcome version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), the European Organisation for Research and Treatment of Cancer (EORTC) Item Library, and the Functional Assessment of Chronic Illness Therapy (FACIT) searchable library. The rates of inter-rater agreement were recorded. Following item collation from the item libraries, we devised criteria for selecting the optimal item for each side effect for inclusion in a future electronic PRO system based on guidance from the above groups. Results All 36 side effects mapped to at least one CTCAE term, with eight mapping to more than one term. Twenty-three side effects mapped to at least one PRO-CTCAE term, 35 side effects mapped to at least one EORTC item, and 31 side effects mapped to at least one FACIT item. The inter-rater agreement rate was 100% (PRO-CTCAE), 83% (EORTC) and 75% (FACIT). Pre-determined criteria were applied to select the optimal item for each side effect from the three item libraries, producing a final 61-item list. Conclusion Using ICI side effects as an example, we developed a pragmatic approach to creating customized item lists from three major item libraries to monitor for side effects of novel therapies in routine care. This process highlighted the challenges of using item libraries and priorities for future work to improve their usability.

What's in store if #HR9495 goes through? Let's revisit this "blast from the past" from 2020...

#FederalAgents Used #ToxicChemical #SmokeGrenades in #PortlandOregon

Portland protesters report severe and lasting #SideEffects from the #ChemicalWeapons used during #Trump’s “#OperationDiligentValor.”

by Sharon Lerner
October 10 2020

"By the time she was standing in front of the federal courthouse on #LownsdaleSquare on the night of July 25, Olivia Katbi Smith had already been exposed to tear gas several times. On those previous occasions during the #BlackLivesMatter #protests in Portland, Oregon, this summer, being gassed had been very unpleasant: leaving her coughing and making her eyes and nose run and sting.

"But this time, standing about 30 feet from the fence that was surrounding the downtown courthouse, Smith felt suddenly and violently worse than she ever had before. 'I didn’t know if I was going to puke or pass out,' she recalled recently. 'I was stumbling, trying to get away.' Smith, who is 28, was wearing goggles plus an N95 mask and thought that whatever was making her ill might have been trapped inside her mask. 'So I made a really bad instinctual decision to take it off,' she said. 'And instead of bringing relief, it instantly felt so much worse, like I was trapped in the air. It was overwhelming. I could not breathe.'

"Smith, like thousands of others in Portland, took to the streets in June to protest the suffocation and killing of #GeorgeFloyd by a police officer. By the beginning of July, the crowds had begun to thin somewhat. But after #Trump decided to send federal law enforcement to the city that month, the number of protesters surged and violence escalated. And according to interviews with more than a dozen people who attended the protests and research by the Portland-based #ChemicalWeapons Research Consortium, there was a marked shift in the use of chemical munitions on the crowds in the second half of July, as the federal agents released greater amounts and different types of smoke and gas onto crowds that seemed to set off severe and sometimes lasting health effects.

"The Portland Police Bureau began using tear gas on Black Lives Matters protesters almost as soon as they first assembled in late May. Mayor Ted Wheeler acknowledged that the city has used '#CSTearGas.' The commonly used formulation contains 2-chlorobenzalmalononitrile, a compound that was designed to induce immediate pain but can also have long-term effects, including chronic bronchitis. In early September, Wheeler ordered the police to stop using it. #TearGas is banned in war but can be used to disperse crowds of civilians.

After federal agents from the #DepartmentOfHomelandSecurity descended on Portland in July in a mission dubbed #OperationDiligentValor,' the use of chemical irritants to control, drive away, and confuse protesters and obscure the actions of law enforcement grew and intensified. Among the products that federal agents appear to have used during the #military-style #crackdown is a #hexachloroethane '#SmokeGrenade' manufactured by a company called #DefenseTechnology and sold as '#MaximumHCSmoke.' Volunteers for the Chemical Weapons Research Consortium collected 20 canisters from the protest area that are the size and shape of the smoke grenades, at least five of which still had Defense Technology labels on them. The group also analyzed the chemical residue on one of the recovered spent canisters and found it contained chemicals known to be released by the smoke grenades."

Read more:
theintercept.com/2020/10/10/po

The Intercept · Federal Agents Used Toxic Chemical Smoke Grenades in PortlandBy Sharon Lerner

To all of the people on T:

Please tell me how long I have to put up with the horrible hot flashes/ soaking sweats?

I skipped my shot this week and within 2 days I noticed a difference. I'm just nowhere near as disgustingly wet on a daily basis after minimal action.

I can't live in a house that's 60°. I can't afford it. Does this ever become easier? Does it ever stop? My doctors just shrug and say yeah testosterone does that.

I've been on T for 2 years now and over a year at my current dose. Brain wise, I'm a lot happier on T but I'm not sure I can live in the body if I just have to deal with epic levels of sweat from activities like dusting or sweeping.

I'm definitely open for advice here. Share this one widely. I know way more trans femmes than I do trans mascs.

#hrt#transman#trans

People with cancer typically assume that side effects from chemotherapy and other drug treatments are part of the tradeoff to treat a life-threatening disease.

But some researchers and patient advocates maintain that the information provided about potential side effects, particularly more subjective ones like pain and fatigue, doesn’t necessarily provide the real-world insights that cancer patients need.

Clinical trials typically are well designed to measure the effectiveness and safety of cancer drugs, but they often don’t similarly capture “the tolerability side” that patients really care about, said Hillary Andrews, director of regulatory and research partnerships for the Friends of Cancer Research, a nonprofit advocacy organization based in Washington, D.C.
“They want to understand how others have experienced this drug, and how it could potentially impact them,” she said.

For instance, a patient’s diarrhea may not be frequent enough to constitute a safety concern but still be urgent enough that someone is reluctant to leave home, Andrews said.

Federal officials have begun to encourage drug study leaders over the last decade to collect more such information related to tolerability, called patient-reported outcomes.
But it’s not required, and neither is the reporting of those patient measures, including on the drug label, she said.
#cancer #chemotherapy #sideeffects
undark.org/2023/12/06/cancer-d

Undark Magazine · The Side Effect Roulette of Cancer TreatmentSome researchers and advocates strive to offer patients a more accurate window into the impact of cancer drugs on daily life.

#FoxNews is pushing out objective #bullshit about medication #abortion. These #liars are desperate to convince #America actual #facts are #lies, and #rightwing lies are facts. To be clear, the rate of serious #complications resulting from the abortion #pill is 0.1%. #Cramping, #bleeding, and #nausea are the most common #sideEffects. But, according to Fox the pill is dropping bodies left and right. These people are a joke. They spew lies and call it an #opinion.

foxnews.com/opinion/chemical-a

Fox News · Chemical abortion harms women. Supreme Court can't ignore themBy Christina Francis