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#vascular

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(((Cindy Weinstein)))

Thank you, dear reader, for this incredibly kind review of #FindingtheRightWords, the #memoir I wrote with #neurologist, #Dr.BruceMiller. #Dementia doesn't take a break for the holidays, which means #caregivers don't get a break either. Sending strength to those of you who are living with #Alzheimer's, caring for someone with it or another form of dementia (#FTD, #CTE, #vascular, #LewyBodies, #early-onset, #Creutzfelt-Jakob, and others), and/or loving someone with #dementia.

5 star Amazon review, "Consequences of Alzheimer's," written in US on December 22, 2023. This is a beautifully written book that captures the consequences of Alzheimer's on the person with dementia -- in this case, Cindy Weinstein's father, Jerry -- and the ones who love/loved him. In addition to describing the pain of early-onset Alzheimer's, the book stands out because of Dr. Bruce Miller's contributions, which explain in clear, comprehensible language the neurology behind the symptoms Cindy describes. A must-read if you, a loved one, or a friend is dealing with dementia.
Public
Jeff Gilchrist

Protect your #brain 🧠 from #LongCovid

"We found significantly increased #neuroinflammation in #PASC versus controls across a wide swath of brain regions... and found significant positive correlations between neuroinflammation and several circulating analytes related to #vascular #dysfunction."

Study: biorxiv.org/content/10.1101/20

Details from the study author ( threadreaderapp.com/thread/171 ).

Info from a physician who sees this all the time ( threadreaderapp.com/thread/171 ).

bioRxiv · Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C]PBR28 PET correlates with vascular disease measuresThe COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used [11C]PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls. We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles. We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction. These results suggest that an interaction between neuroinflammation and vascular health may contribute to common symptoms of PASC. ### Competing Interest Statement The authors have declared no competing interest.
Public
Auscandoc

elevated #vascular #endothelial cell turnover and #erythropoiesis in #asymptomatic #COVID19 patients | biorxiv.org/content/10.1101/20 “Asymptomatic patients had elevated levels of immune-derived cfDNA but did not show evidence of #pulmonary or #cardiac damage. Surprisingly, these patients showed elevated levels of vascular endothelial cell and erythroblast cfDNA, suggesting that sub-clinical vascular and erythrocyte turnover are universal features of COVID19, independent of disease #severity.

bioRxiv · Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patientsThe full spectrum of tissues affected by SARS-CoV-2 infection is crucial for deciphering the heterogenous clinical course of COVID-19. Here, we analyzed DNA methylation and histone modification patterns in circulating chromatin to assess cell type-specific turnover in severe and asymptomatic COVID-19 patients, in relation to clinical outcome. Patients with severe COVID-19 had a massive elevation of circulating cell-free DNA (cfDNA) levels, which originated in lung epithelial cells, cardiomyocytes, vascular endothelial cells and erythroblasts, suggesting increased cell death or turnover in these tissues. The immune response to infection was reflected by elevated B cell and monocyte/macrophage cfDNA levels, and by evidence of an interferon response in cells prior to cfDNA release. Strikingly, monocyte/macrophage cfDNA levels (but not monocyte counts), as well as lung epithelium cfDNA and vascular endothelial cfDNA, predicted clinical deterioration and duration of hospitalization. Asymptomatic patients had elevated levels of immune-derived cfDNA but did not show evidence of pulmonary or cardiac damage. Surprisingly, these patients showed elevated levels of vascular endothelial cell and erythroblast cfDNA, suggesting that sub-clinical vascular and erythrocyte turnover are universal features of COVID-19, independent of disease severity. Epigenetic liquid biopsies provide non-invasive means of monitoring COVID-19 patients, and reveal sub-clinical vascular damage and red blood cell turnover. ### Competing Interest Statement BG, RS and YD have filed patents related to DNA methylation markers. NF is a co-founder and shareholder of Senseera Inc. IS is a shareholder of Senseera Inc.
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ProPublica

Blocked Artery in Your Leg? Here’s What You Should Know.
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A ProPublica investigation found that some #doctors overuse invasive #treatments for peripheral artery disease. So we talked to experts to learn what #vascular #patients should know when seeking care.

#Health #HealthCare

propublica.org/article/what-to

ProPublicaBlocked Artery in Your Leg? Here’s What You Should Know.
More from ProPublica
Continued thread
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Barry Phillips Smith

Hey guess what! I had two more attacks on Sunday, so I've had a full MOT and its not TIAs (mini-strokes) at all - its a #brain #lesion (tumour/cyst - TBD) causing #seizures instead. Primary, not secondary, and almost certainly treatable, so I should get a bit more adventuring out of this otherwise now proven, poked, prodded, blood-tested, ultrasounded, CT scanned, X-rayed and MRI'd (!) healthy body!

Bright side - its not #vascular #dementia like my Dad, so I shouldn't end up drooling in a care home for years, and I'll probably go pretty quick when I finally hang up my boots if the cards fall that way - hopefully many years hence! ✅ 👍

Public
ProPublica

In the “Wild West” of Outpatient Vascular Care, #Doctors Can Reap Huge Payments as #Patients Risk Life and Limb
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To move #vascular procedures out of expensive #hospitals, the government turbocharged payments to doctors’ offices.

Instead of saving money, it started a boom that is making doctors rich and putting patients in danger.

#Health #HealthCare #Medicaid #Medicare #CMS #Maryland #Surgery

propublica.org/article/marylan

ProPublicaIn the “Wild West” of Outpatient Vascular Care, Doctors Can Reap Huge Payments as Patients Risk Life and LimbTo move vascular procedures out of expensive hospitals, the government turbocharged payments to doctors’ offices. Instead of saving money, it started a boom that is making doctors rich and putting patients in danger.
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