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#sars

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in some #COVID infections, #SARS-CoV-2 may dramatically impair the immune response by reprogramming neutrophils—front-line immune cells central to fighting infections—into a cell type called polymorphonuclear myeloid derived suppressor cells, or PMN-MDSCs [...] which are known to suppress virus-fighting immune cells known as T lymphocytes, or T cells

medicalxpress.com/news/2025-05

Medical Xpress · COVID virus 'reprograms' infection fighters into immune system suppressors, study showsBy Michael E. Newman
Replied in thread

«  Cibler les réservoirs de SARS-CoV-2 dans le Covid long »

Étude
sciencedirect.com/science/arti
Vulgarisation en français (fil)
bsky.app/profile/apresj20.bsky

« Le #SARS-CoV-2 peut persister dans l’organisme pendant des mois, voire des années, chez certains patients.
Ce rapport, rédigé par 36 experts de 20 institutions, propose une feuille de route pour cibler ces réservoirs viraux et tester des traitements.
Vulgarisation en anglais (article) : polybio.org/cutting-edge-recom

#ARRAVeille
29/71

www.sciencedirect.comTargeting the SARS-CoV-2 reservoir in long COVIDThere are no approved treatments for post-COVID-19 condition (also known as long COVID), a debilitating disease state following SARS-CoV-2 infection t…
Replied in thread

Omni Mask: a clear / transparent / see-through / accessible thing to protect you from pathogens, the microbes that make you sick.

More than 51% of Autistic scholars agree: this is the *good* kind of masking in public! #ActuallyAutistic or @actuallyautistic may confirm.

anything on FB is now technophobe outreach -- which, if you have the patience for it, is immensely helpful.
Even just simple, blanket statements really help e.g.

Face masks reduce your risk of catching illnesses.
Face masks reduce your risk of developing serious illnesses.
FFP3 respirators are good-quality, safe face masks.
Sanitise or replace your respirator regularly to maintain protection from illnesses.

facebook.com/OmniMaskHealth

FacebookLog into FacebookLog into Facebook to start sharing and connecting with your friends, family, and people you know.

🇩🇪

CN #SARS #CovidIsNotOver #Corona #LongCovid #MECFS #Covid19

Da die offiziellen Zahlen zum aktuellen Infektionsgeschehen um Größenordnungen zu niedrig kommuniziert werden, habe ich für Deutschland und die einzelnen Bundesländer ein Dashboard mit einer Schätzung der realen Zahlen auf Basis der Hospitalisierungen und kalibriert mit Abwasserdaten entwickelt.

Die Daten werden täglich und automatisch aktualisiert.

Weitere Informationen unter:

covidisnotover.info/aktuelle-c

Replied in thread

@RebelGeek99 @mike_honey_ also the fact that the "P.R." China rather covered it up (as that would shed a light on the whole wet market issue and the lack of basic sanitary standards being enforced at all, cuz other places in Asia have wet markets yet they don't have that issue - I wounder why?) since at least August 2019 (when it was widespread knowledge among doctors in China) debunks any "lab leak" theory as the lack of lethality and other key indices point against it.

  • There are way better, more dangerous and more lethal pathogens than #SARS that are way easier to get into a "weapons-grade" configuration. #COVID19 has orders of magnitude too low #lethality and is way too contagious...

"We urgently need to learn from what happened here. The worst pandemic in more than a century, driven by the dangerous and highly contagious virus #SARS-CoV-2, should have energized and unified us. #COVID was the real enemy. But instead, the pandemic tore us apart. False claims gained a rapid foothold, and the sources (including me) that were supposed to share objective information, admit uncertainty, and inspire public trust often failed to achieve that." theatlantic.com/ideas/archive/

The Atlantic · Why Didn’t Facing a Common Enemy Bring Us Together?By Francis S. Collins

「速報: 米国で新型コロナウイルス感染症が急増。米国人の40人に1人が感染、1日当たりの感染者数は100万人を超えると予想

PMCの最新予測によると、米国は新型コロナウイルス感染症の深刻な急増を経験しており、現在米国人の40人に1人が感染しているという。

同国では来月を通じて毎日100万人以上の新規感染者が発生すると予想されており、この時期としては過去最高の感染期間の一つを記録することになる。 」

ほんとかな。確かに #COVID19 死が私の記録でも増えてるような。

prattohome.com/@ottoto2017/113

mastodon.social/@COVID19_DISEA

#prattohome #SARS-CoV-2(COVID-19)

Mastodonottoto (@ottoto2017@prattohome.com)Attached: 2 images #COVID19 の最新データ(9/14) を表に。 #厚労省の #定点観測 データの最新データ( #9月2日 ~9月8日)更新(次回 、9月20日 金)。 #推定1日平均新規感染者数は、前々回 #増加 に転じたが、今回は前回に引き続き減少が続く。今後の報告を注視。 自分の身は自分で守ろう。 #WHO / #Europe , #EU/EEA , 米国 #CDC のデータで、 #新規入院者数 、 #新規死亡者数 を提供している国/地域のみ週データを掲載する。 米CDC、Europe(イタリアは34週)ともに2024年36週まで更新。なんとなく、各国で感染拡大の兆候。 WHO/Global はデータ提供を中止。 なんて役に立たない組織! #prattohome #統計 #コロナ

Recently, I had conversations with 2 people who turned out to be vaccine skeptics. They stopped getting #COVID vaccines after their first jab or two. So, I told them about the 30+ year history behind mRNA vaccine development. That it has been (and continues to be) worked on for treating cancer as well as for other diseases. And that mRNA vaccines were part-way developed for #SARS during the 2002-2004 outbreak (but work stopped because the infection petered out for various reasons) and for Zika. And that when the pandemic came along, most of the pieces of for creating an #mRNA #vaccine for COVID were already in place -- which is why the the vaccines came out relatively quickly. And that they underwent clinical trials before they were approved for release.
Both conversations ended with "Wow, I didn't know any of that. You've given me something to think about."
I'll take it as a win.
Sometimes it's #history more than #science that can help get a message across.

Sources:
1.Timeline: niaid.nih.gov/diseases-conditi
2. One of the best summaries of the mRNA vaccine and its history. statnews.com/2020/11/10/the-st

#publichealth @medmastodon #medmastodon #IDmastodon

There is strong evidence of brain-related abnormalities in COVID-19.

However, it remains unknown whether the impact of #SARS-#CoV-2 infection can be detected in milder cases,
and whether this can reveal possible mechanisms contributing to brain #pathology.

Here we investigated #brain #changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging,

including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans
—with 141 days on average separating their diagnosis and the second scan
—as well as 384 controls.

The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects.

We identified significant longitudinal effects when comparing the two groups, including

(1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus;

(2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and

(3) a greater reduction in global brain size in the SARS-CoV-2 cases.

The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points.

Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised.

These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways,
of neuroinflammatory events,
or of the loss of sensory input due to anosmia.

Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.

nature.com/articles/s41586-022

NatureSARS-CoV-2 is associated with changes in brain structure in UK Biobank - NatureAfter infection with SARS-CoV-2, individuals show a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and a greater reduction in global brain size.

Had a mild #COVID19 infection?
Doesn’t mean it’s mild.

#SARS-Cov-2 can behave like HIV or Polio. It can cause internal damage long after apparent recovery.

Mild initial infection does not = mild disease.

Multiple studies show this. #LongCovid
nbcnews.com/health/health-news

NBC News · Long Covid: Even mild Covid is linked to damage to the brain months after infectionBy Benjamin Ryan