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#DevBio

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Our latest preprint:

It is very useful to be able to measure the properties of individual cells in relation to their neighbours in 3D tissues, but it is also complicated & difficult

The talented Matt French devised computational approaches that helped us overcome many of these difficulties

This helps us work out when where & how cells make differentiation decisions by talking to their neighbours during axis elongation

Hope it's useful! Comments welcome

#DevBio

biorxiv.org/content/10.1101/20

bioRxiv · A toolkit for mapping cell identities in relation to neighbours reveals Notch-dependent heterogeneity within neuromesodermal progenitor populationsPatterning of cell fates is central to embryonic development, tissue homeostasis, and disease. Quantitative analysis of patterning reveals the logic by which cell-cell interactions orchestrate changes in cell fate. However, it is challenging to quantify patterning when graded changes in identity occur over complex 4D trajectories, or where different cell states are intermingled. Furthermore, comparing patterns across multiple individual embryos, tissues, or organoids is difficult because these often vary in shape and size. Here we present a toolkit of computational approaches to tackle these problems. These strategies are based on measuring properties of each cell in relation to the properties of its neighbours to quantify patterning, and on using embryonic landmarks in order to compare these patterns between embryos. We use this toolkit to characterise patterning of cell identities within the caudal lateral epiblast of E8.5 embryos, revealing local patterning in emergence of early mesoderm cells that is sensitive to inhibition of Notch activity. ### Competing Interest Statement The authors have declared no competing interest.

#Introduction

Hello!

I'm a synthetic developmental biologist at The University of Edinburgh.

I'm interested in understanding how cells influence their neighbours in mammalian models of #DevBio and disease.

I use #SynBio to identify neighbours of cells of interest (e.g. healthy neighbours of mutant cells), and to engineer cell behaviour in response to these interactions.

I do this in pluripotent #StemCells and their derivatives.

I look forward to keeping up with everyone's cool research!

Hey there!
I'm a French researcher in developmental biology, focusing on mammalian sex determination and gonadal development at the genetic level. I have a PhD in bioinformatics but I do wet and dry lab.
I am a free (as in freedom) and open source software advocate, formerly actively involved in FOSS groups.
I love dataviz, photography, classic rock music, and playing video games.
I moved from another Mastodon instance.
#introductions #stem #DevBio #genetics #genomics #transcriptomics #SexDet

Hi #ScienceMastodon. We, @Dev_journal are a community journal covering all areas of #devbio. Development is led by Editor-in-Chief James Briscoe & published by the not-for-profit @Co_Biologists.

We will toot about #research papers, #reviews, #interviews, charitable activities, and news from @the_node.

We’ve moved over to our own instance @biologists.social, & hope that you’ll join us there for friendly chats between biologists!

biologists.social/about

Hi #ScienceMastodon. The Node (thenode.biologists.com) is the community website for and by #devbio and #stemcell biologists, where you can read the latest news and stories, check out jobs and events pages and interact with colleagues from around the world.

The Node is run by the journal @Dev_journal and its publisher, @Co_Biologists.

We’ve moved over to our own instance @biologists.social, & hope that you’ll join us there for friendly chats between biologists!

biologists.social/about

Hi everyone. We’re #Co_Biologists, a not-for-profit #publisher dedicated to inspiring the #biology community:

- We publish five #journals: @Dev_journal @J_Cell_Sci @J_Exp_Biol @DMM_Journal & @BiologyOpen
- We facilitate scientific #meetings & provide #grants for #researchers
- We run three #community sites: @the_node @preLights @focalplane_jcs
- We are committed to #OpenAccess
- We have initiatives to support early-career researchers #ECRs

Hi everyone!

The Vincent lab twitter account completes its migration to Mastodon.
Follow us for cool #DevBio science, mostly working with #Drosophila. We are generally interested in the signalling activities that control patterning, growth and apoptosis in epithelia. Our #morphogen of choice is #Wnt.

Here you may also find the occasional rant from JP once he gets used to the new format. Until then, this account is mostly managed by postdoc Ines.

Hi #ScienceMastodon, time for an #introduction!

I'm an #EvoDevo biologist interested in how tissue #mechanics influences the #evolution of #morphogenesis. I study a deep and mysterious epithelial invagination that forms at the head-trunk boundary of #flies during #gastrulation, known as the #CephalicFurrow (see video below!). Currently, based in Germany as a postdoc in the Tomancak Lab at MPI-CBG. Looking forward to meeting you!

After scoping out Mastodon for about a week now, it's probably time for an #introduction

Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.

I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.

Hi everyone. We’re #Co_Biologists, a not-for-profit #publisher dedicated to inspiring the #biology community:

- We publish five #journals: @Dev_journal @J_Cell_Sci @J_Exp_Biol @DMM_Journal & @BiologyOpen
- We facilitate scientific #meetings & provide #grants for #researchers
- We run three #community sites: @the_node @preLights @focalplane_jcs
- We are committed to #OpenAccess
- We have initiatives to support early-career researchers #ECRs

#Introduction

Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.

We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.

Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown

Introduction #DevBio #DevBiol #Science #Embryos #StemCells #Epigenetics #Transcription #Neuroscience #Autism #NeurodevelopmentalDisorders
My lab at Washington University School of Medicine studies transcriptional and epigenetic regulation of brain development, using human stem cell and organoid and mouse models. We are interested in defining networks that regulate formation of particular neuronal cell types and learning how these are disrupted to cause neurodevelopmental disorders like autism.

#introduction time!

I'm Les, I've been a research tech at Washington University School of Medicine in the Chen lab for the past 2 years - we study the epigenetic shift from pre-malignant to malignant skin #cancer

I'm planning on pursuing a PhD in #devbio or #cellbio, ending up doing research + #scicomm

outside of science, I love coffee, my cats, doing mutual aid work, studying relationship theory, and continuing to be a learner in all fields!

Excited to be here ✨