"Nearly one in ten unsure if they have Long Covid. Almost 5% have the condition and socially disadvantaged groups are most affected"
https://www.eurekalert.org/news-releases/1076866

Free paper:
https://onlinelibrary.wiley.com/doi/10.1111/hex.70202

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

News Release 17-Mar-2025
Nearly one in ten unsure if they have Long Covid
Almost 5% have the condition and socially disadvantaged groups are most affected

Peer-Reviewed Publication
University of Southampton

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UNDER EMBARGO UNTIL 00:01 AM UK TIME ON TUESDAY 18 MARCH 2025

Almost one in ten people (9.1%) in England think they could have Long Covid but aren’t sure, according to a new analysis of NHS England survey data by the University of Southampton.

**Tom Kindlon** @tomkindlon@disabled.social · Mar 17

Mar 17

Tom Kindlon @tomkindlon@disabled.social

Five years of Long Covid

Links:
NBC News
https://www.nbcnews.com/health/health-news/5-years-later-long-covid-still-medical-mystery-scientists-learned-rcna195608

US News and World Report:
https://www.usnews.com/opinion/articles/2025-03-10/covid-pandemic-vaccines-measles

Rolling Stone:
https://www.rollingstone.com/culture/culture-features/long-covid-five-years-1235296375/

https://www.s4me.info/threads/news-from-the-usa-united-states-of-america.20771/page-36#post-593840

From the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Five years of Long Covid

The five year anniversary of the start the COVID-19 pandemic has prompted several media outlets to publish stories on Long Covid.

NBC News: 5 years later, long Covid is still a medical mystery: What scientists have learned

US News and World Report: 5 Years Since the COVID-19 Pandemic, Millions Like Me Are Still Sick

Rolling Stone: Five Years of Pain, Fatigue, and Gaslighting: Life With Long Covid

More stories in this Thread

**Tom Kindlon** @tomkindlon@disabled.social · Mar 12

Mar 12

Tom Kindlon @tomkindlon@disabled.social

From Denmark:
Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID

https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.70275

From the latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Journal of Medical Virology
Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID — Kristoffer Skaalum Hansen et al.
"In this effort to establish patterns of underlying genetic predisposition for the development of long COVID, we performed comprehensive genomic analysis with a focus on genes related to mitochondrial function on 13 patients with a severe long COVID phenotype dominated by neurological and muscular symptoms/myopathy."

**Tom Kindlon** @tomkindlon@disabled.social · Mar 12

Mar 12

Tom Kindlon @tomkindlon@disabled.social

From Hungary & the Netherlands:

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in #COVID19

https://www.nature.com/articles/s41593-025-01871-z

From Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Nature Neuroscience
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 — Fekete et al.
"COVID-19 is associated with IL-1- or IL-6-related proinflammatory responses at sites of viral antigens, vascular inflammation, BBB injury and microglial dysfunction across the brain, particularly in central autonomic nuclei."

**Tom Kindlon** @tomkindlon@disabled.social · Mar 12

Mar 12

Tom Kindlon @tomkindlon@disabled.social

From Germany:

Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19

https://oparu.uni-ulm.de/items/fc17b8f9-dfd3-456d-896e-bcfeafd10d4f

From the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Thesis: Ulm University
Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 — Czech
"Except for one outlier, the viral matter could not be associated with pathological processes, challenging the hypothesis that unresolved viral presence is the cause of chronic inflammation. The observations suggest that PASC represents a post-viral pathological process driven by bronchiolitis. The histological, serological, and radiological results within this PASC cohort align with the criteria of bronchiolitis following a mild COVID-19 infection."

**Tom Kindlon** @tomkindlon@disabled.social · Mar 11

Mar 11

Tom Kindlon @tomkindlon@disabled.social

Longhauler Advocacy Project @C19LAP Webinar on Long COVID and the Future of Public Health

https://zoom.us/webinar/register/WN_Vug5fHumTT-TKFRDPo3lSA#/registration?utm_source=newsletter&utm_medium=email&utm_campaign=march-newsletter-web-link

From Massachusetts ME/CFS & FM Association e-newsletter
https://www.massmecfs.org/newsletters/919-2025-03-march-newsletter

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

Webinar on Long COVID and the Future of Public Health

The COVID-19 Longhauler Advocacy Project (C19LAP) is holding a webinar on March 12th with Michael Osterholm, director of the Center for Infectious Disease Research and Policy, and C19LAP Founder Karyn Bishof called "Five Years Later: The ongoing COVID and Long COVID Crisis and the Future of Public Health".

This conversation will review the state of COVID five years after the pandemic, reflect on what has been learned, where public health went wrong, and how we can prevent further harm. Register here.

**Tom Kindlon** @tomkindlon@disabled.social · Mar 10

Mar 10

Tom Kindlon @tomkindlon@disabled.social

(USA)

#MEAction @meactnet and the Patient-Led Research Collaborative @patientled
have written an open letter to HHS director Robert F. Kennedy, Jr. calling for him to reinstate the #LongCOVID Advisory Committee.

https://www.meaction.net/2025/03/06/press-release-advocates-urge-administration-to-reinstate-long-covid-advisory-committee/

@longcovid
#PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver #auscovid19

#MEAction Network · Mar 6Press Release: Advocates Urge Administration to Reinstate Long COVID Advisory CommitteePress Contact: #MEAction: press@meaction.net Patient & Expert Voices Must Be Heard: Advocates Urge Administration to Reinstate Long COVID Advisory Committee #MEAction and the Patient-Led Research Collaborative – leading organizations advocating for people with Long … Press Release: Advocates Urge Administration to Reinstate Long COVID Advisory Committee Read More »

**Tom Kindlon** @tomkindlon@disabled.social · Mar 6

**Tom Kindlon** @tomkindlon@disabled.social · Mar 5

Mar 5

Tom Kindlon @tomkindlon@disabled.social

"The association between low anti-#SARSCoV2-spike antibodies during acute COVID-19 & #longCOVID suggests that maintaining sufficiently high antibody levels may be protective"

https://onlinelibrary.wiley.com/doi/abs/10.1002/rmv.70027

From latest Science for ME weekly update

Hashtags:
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Reviews in Medical Virology
Anti-SARS-CoV-2 Antibodies in Long-COVID—Markers of Protection or Elevated Risk? A Systematic Review — Sylvia Mink et al.
"The association between low anti-SARS-CoV-2-spike antibodies during acute COVID-19 and long-COVID suggests that maintaining sufficiently high antibody levels may be protective. However, the current evidence level is low and further studies with sufficient power are required"

**Tom Kindlon** @tomkindlon@disabled.social · Feb 27

Feb 27

Tom Kindlon @tomkindlon@disabled.social

From Germany:

Altered corticostriatal connectivity in long-COVID patients is associated with cognitive impairment

Image is from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Psychological Medicine
Altered corticostriatal connectivity in long-COVID patients is associated with cognitive impairment — Marie Troll et al.
"Patients with long-COVID present enhanced [Functional Connectivity] between the caudate and the left precentral gyrus. Furthermore, those FC alterations are related to the severity of cognitive impairment, particularly in the domain of executive functions."

**Tom Kindlon** @tomkindlon@disabled.social · Feb 19

Feb 19

Tom Kindlon @tomkindlon@disabled.social

"Long COVID Cure Would Make RFK, Jr. a Hero" By Susan Estrich

https://www.newsmax.com/estrich/long-covid-robert-f-kennedy-jr/2025/02/18/id/1199512/

Includes some discussion of ME/CFS & POTS

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #POTS @pots @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

**Tom Kindlon** @tomkindlon@disabled.social · Feb 18

Feb 18

Tom Kindlon @tomkindlon@disabled.social

Impact of Pre-Infection COVID-19 Vaccination on the Incidence and Severity of Long COVID: A Retrospective Case–Control Study

https://onlinelibrary.wiley.com/doi/10.1111/imm.13908

Screenshot from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Immunology
Impact of Pre-Infection COVID-19 Vaccination on the Incidence and Severity of Long COVID: A Retrospective Case–Control Study — Elena Barado et al.
"In this study, complete vaccination prior to acute COVID-19 infection is associated with a reduction in the risk of developing long COVID in the multivariate analysis. Within the population affected by long COVID, complete vaccination before acute infection is associated with a reduction in long COVID symptoms and a reduced overall symptom count."

**Tom Kindlon** @tomkindlon@disabled.social · Feb 18

Feb 18

Tom Kindlon @tomkindlon@disabled.social

Targeting the SARS-CoV-2 reservoir in long COVID

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00769-2/abstract

Screenshot from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

The Lancet Infectious Diseases
Targeting the SARS-CoV-2 reservoir in long COVID — Amy D Proal et al.
"a growing body of research centres around the persistence of SARS-CoV-2 as a driver of disease in at least some individuals." "Here, we draw from RNA virus biology, efforts to target the HIV reservoir, and clinical oncology to outline major considerations for the design and implementation of trials targeting SARS-CoV-2 persistence in long COVID."

**Irish ME/CFS Association** @IrishMECFSAssociation@mastodon.ie · Feb 15

Feb 15

Irish ME/CFS Association @IrishMECFSAssociation@mastodon.ie

Association of cognitive deficits with sociodemographic characteristics among adults with #postCOVID conditions: Findings from the United States household pulse survey

https://dx.doi.org/10.1093/biomethods/bpaf006

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid19 #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Biology Methods and Protocols
Association of cognitive deficits with sociodemographic characteristics among adults with post-COVID conditions: Findings from the United States household pulse survey — Wu and Liu
"This study based on a large cohort representative of the US adult population has found significant differences in the cognitive outcomes associated with COVID infections among various sociodemographic groups. Individuals who are older or highly educated are more vulnerable to cognitive deficits"

**Irish ME/CFS Association** @IrishMECFSAssociation@mastodon.ie · Feb 15

Feb 15

Irish ME/CFS Association @IrishMECFSAssociation@mastodon.ie

Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1465787/full

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Frontiers in Neurology
Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics — Talkington et al.
"In this review, we explore the mechanistic hypotheses of these neurological changes, which describe CNS invasion, neuroinﬂammation, blood-brain barrier disruption, and gut-brain axis dysregulation, along with the novel vascular disruption hypothesis that highlights endothelial dysfunction and hypoperfusion as a core underlying mechanism."

**Irish ME/CFS Association** @IrishMECFSAssociation@mastodon.ie · Feb 15

Feb 15

Irish ME/CFS Association @IrishMECFSAssociation@mastodon.ie

"Reproducibility of Genetic Risk Factors Identified for #LongCOVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries"

https://www.medrxiv.org/content/10.1101/2025.02.04.25320937v1

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: MedRxiv
Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries — Jason Sardell et al.
"These findings redefine our understanding of long COVID by uncovering a broad spectrum of reproducible genetic signatures, laying the foundation for new diagnostic innovations and targeted therapies that have the potential to revolutionize care for millions suffering from this debilitating condition worldwide."

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