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“Broadly stated, the imagination has five steps: mimicry; abstraction/decoupling; recombination; expression; and social feedback.“
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#recombination
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Hi everybody,
I am pleased to share with you my latest work in collaboration with Augustin Cléssin and Nicolas Lartillot:
https://www.biorxiv.org/content/10.1101/2024.06.21.600052v1
GC-biased gene conversion (gBGC) is a process that distorts the segregation of heterozygous AT:GC polymorphisms during meiotic #recombination. This genome-wide non-Mendelian segregation has been shown to be a major source of #genetic load, earning the nickname of “Achille’s heel” of #genomes. (1/2)
bioRxiv · The evolution of GC-biased gene conversion by means of natural selectionGC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that biases the segregation ratio of AT:GC polymorphisms in the gametes of heterozygotes, in favour of GC alleles. This process is the major determinant of variation in base composition across the human genome and can be the cause of a substantial burden of GC deleterious alleles. While the importance of GC-biased gene conversion in molecular evolution is increasingly recognised, the reasons for its existence and its variation between species remain largely unknown. Using simulations and semi-analytical approximations, we investigated the evolution of gBGC as a quantitative trait evolving by mutation, drift and natural selection. We show that in a finite population where most mutations are deleterious, gBGC is under weak stabilising selection around a positive value that mainly depends on the intensity of the mutation bias and on the intensity of selective constraints exerted on the genome. Importantly, the levels of gBGC that evolve by natural selection do not minimize the load in the population, and even increase it substantially in regions of high recombination rate. Therefore, despite reducing the population’s fitness, levels of gBGC that are currently observed in humans could in fact have been (weakly) positively selected.
### Competing Interest Statement
The authors have declared no competing interest.
What are the dynamics of #recombination in natural bacterial populations? Zhiru Liu & @benjaminhgood use #metagenomics to quantify the recombination landscape in ~30 common species of human #GutBacteria, revealing widespread variation within and across species #PLOSBiology https://plos.io/3wbs5NP
Hi 
folks! I'm a postdoc at the University of North Carolina, doing #Theory in #EvolutionaryBiology 
I'm mainly working on #popgen, #speciation and #recombination, but I'm also very interested in the evolution of #senescence, #cooperation, #mimicry, and many other topics!
Really excited to be joining 
!
I am Susan & I study how evolutionary trade-offs affect genetic variation in wild and domesticated species. I am a middling-at-best quantitative geneticist who has made a career off of using obscure 1990s linkage mapping softwares and running the odd GWAS.
I head a research group in Edinburgh. We are interested in #recombination #meiosis #chromosomes #sexualconflict #immunity and have worked on 
in 
.
Excited to join this new (old) community 