Alternative transcription start site (altTSS) usage in non-yeast #fungi: @vidang411 @guilhemjanbon &co reveal widespread altTSS in #Cryptococcus, altering gene expression & protein targeting, regulated by Tur1 in response to environmental cues #PLOSBiology https://plos.io/3A9RyJ6
Do related pathogenic and non-pathogenic #fungi evolve differently? @MarcoACoelho1 @MrciaDavidPalm1 @DukeHeitman &co analyze #genomic evolution of #Cryptococcus & #Kwoniella, highlighting distinct mechanisms that drive diversity & lifestyles #PLOSBiology https://plos.io/3XfJXSW
Pretty exciting to see oral amphotericin behaving comparably to IV amphotericin for #HIV associated #Cryptococcus #meningitis
Phase 2 open label #RCT, so not quite there yet, but big potential win in simplicity and access to treatment for
#Cryptococcusneoformans & other #fungal diseases, potentially even #mucor
#infectiousdiseases #mycology #IDMastodon #MedMastodon #medicine @infectiousdiseases
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad440/7246927
