"The Trump administration has terminated a federal advisory committee that issued guidance about preventing the spread of infections in health care facilities.
The Healthcare Infection Control Practices Advisory Committee (HICPAC) crafted national standards for hand-washing, mask-wearing and isolating sick patients that most U.S. hospitals follow."
Honestly, i'd never heard of spectinamides!
#IDMastodon #antibiotics #TB
A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides https://elifesciences.org/articles/96190
1/2
Recently, I had conversations with 2 people who turned out to be vaccine skeptics. They stopped getting #COVID vaccines after their first jab or two. So, I told them about the 30+ year history behind mRNA vaccine development. That it has been (and continues to be) worked on for treating cancer as well as for other diseases. And that mRNA vaccines were part-way developed for #SARS during the 2002-2004 outbreak (but work stopped because the infection petered out for various reasons) and for Zika. And that when the pandemic came along, most of the pieces of for creating an #mRNA #vaccine for COVID were already in place -- which is why the the vaccines came out relatively quickly. And that they underwent clinical trials before they were approved for release.
Both conversations ended with "Wow, I didn't know any of that. You've given me something to think about."
I'll take it as a win.
Sometimes it's #history more than #science that can help get a message across.
Sources:
1.Timeline: https://www.niaid.nih.gov/diseases-conditions/decades-making-mrna-covid-19-vaccines
2. One of the best summaries of the mRNA vaccine and its history. https://www.statnews.com/2020/11/10/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race/
Evidence for role of microbiome being important in the susceptibility to infections increases.
Here, more butyrate producing bacteria = lower risk of infections
We're still at association level evidence though. Interventions needed now #microbiome #medicine #IDmastodon #infectiousdiseases
This is a review with a very high citation potential in the decades to come!!! 
#infectiousdiseases #microbiology #medicine #space #travel #IDMastodon
Infections in long-duration space missions
Ontario's wastewater testing program to be replaced by a federal program that is significantly smaller.
#COVID #flu #publichealth #medicine #MedMastodon @medmastodon #IDmastodon
https://www.msn.com/en-ca/news/canada/ontario-s-wastewater-testing-program-to-be-replaced-by-a-federal-program-that-is-significantly-smaller/ar-BB1nL8p2
And we're ready to go again...
Delighted to announce the 2nd UCL Advances and Innovations in Clinical Infectious Diseases symposium
Focus on research shaping Infectious Diseases practice in next few years
4th June 2024. In person & online. Register 
https://uclinfectioncourses.wordpress.com/2024-event/ #medicine #IDMastodon #infectiousdeseases #academia #science
2 weeks to UCL / LSHTM World TB Day 2024 event! 
Not too late to grab a (free!) place, in person or online.
Reserve your spot here
https://www.eventbrite.co.uk/e/world-tb-day-symposium-2024-tickets-807888485207?aff=oddtdtcreator #TB #IDMastodon #infectiousdiseases #tuberculosis
Clinical surveillance alone misses many cases of cholera.
TBH, probably not that surprising, but still an important conclusion and focuses minds on means to interrupt transmission. #infectiousdiseases #IDMastodon #medicine
Simple clear message: avoid typhoid over-diagnosis & prevent real cases through vaccine. Both 
lower use of ciprofloxacin lower ciprofloxacin resistance for when you really need to use it.
#IDMastodon #infectiousdiseases #microbiology #medicine #AMR
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00327-0/fulltext?dgcid=raven_jbs_aip_email
A less effective antibiotic results in lower cure rates. Not surprising per se, but the real issue is how can we find out the C difficile MIC when deciding how best to treat patients?
#IDMastodon #medicine #InfectiousDiseases #AMR
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae087/7612213
This feels quite obvious to me, have to say.
Persistent blood stream infection -> more likely that infection recurs even after treatment. #infectiousdisease #IDMastodon #microbiology #antibiotics
Something doesn't add up here.
Cefepime–Taniborbactam vaunted for activity vs carbapenem resistant organisms, but in this study looks like was compared to meropenem in cUTI not due these resistant organisms! (appendix not that clear)
#UTI #AMR #infectiousdiseases #IDMastodon #antibiotics https://www.nejm.org/doi/full/10.1056/NEJMoa2304748?query=TOC&cid=NEJM%20eToc,%20February%2015,%202024%20DM2324746_NEJM_Non_Subscriber&bid=2100307833
It's that time again - World TB Day is nearly upon us!
We've put together a stimulating and wide-ranging programme (screenshots).
Do join us in person or online if you can.
#infectiousdiseases #TB #medicine #Science #tuberculosis #IDMastodon
https://www.eventbrite.co.uk/e/world-tb-day-symposium-2024-tickets-807888485207?aff=oddtdtcreator
I don't understand why this is even news. What next, raw sewage?!?
#IDMastodon #medicine #InfectiousDiseases #milk
No, you don’t need to be drinking raw milk
> Thanks to TikTok, raw milk is growing in popularity. But health experts are appalled
Do people remember the surge in cases of pneumonia in China in July 2023?
Well thankfully wasn't a new pandemic virus, but in fact was a story about antibiotic resistance!
Was a surge in cases of Mycoplasma pneumonia, resistant to most commonly used antibiotic class 'macrolides' - e.g. Azithromycin, clarithromycin, erythromycin
#AMR #infectiousdiseases #IDMastodon #antibiotics #medicine
Use antibiotics wisely!
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00405-6/fulltext
Interested in TB? Interested in HLH?
Then check out our systematic review & meta-analysis on TB-associated cases of HLH.
Fab collaboration BETWEEN clinical research teams at UCL & @Radboud_uni
#medicine #infectiousdiseases #IDMastodon #HLH #inflammation #TB #tuberculosis
So what did we find?
Keep away from deer (to avoid getting Mycobacterium bovis!)
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae009/7517025?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner
#IDMastodon #infectiousdiseases #microbiology #medicine
*WHAT THIS PAPER MEANS*
Blood stream infections (sepsis) in newborn babies are a v bad thing! Diagnosing them is actually quite hard - we use clinical signs and some blood tests This paper does a v deep dive into immune responses in these babies and finds the protein amphiregulin may be a more sensitive way to make a sepsis diagnosis.
Next questions:
can this be reproduced? what does amphiregulin do?
#scicomm #medicine #infectiousdiseases #IDMastodon #Science
for TB in prisons