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#prion

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PLOS Biology<p>TMED9 mediates export of misfolded <a href="https://fediscience.org/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> proteins from the ER. This study shows that TMED9 also helps capture <a href="https://fediscience.org/tags/misfolded" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>misfolded</span></a> GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>PLOSBiology</span></a></span> <a href="https://plos.io/44kURu5" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/44kURu5</span><span class="invisible"></span></a></p>
Scientific Frontline<p>Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> disease that extends lifespan by about 50 percent in a mouse model of the fatal <a href="https://mastodon.social/tags/neurodegenerative" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neurodegenerative</span></a> condition. <br><a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroscience</span></a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Genetics</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2025/01/ns01142501.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2025/01/ns01142501.</span><span class="invisible">html</span></a></p>
Scientific Frontline<p>Protein aggregation is typical of various <a href="https://mastodon.social/tags/neurodegenerative" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neurodegenerative</span></a> diseases such as <a href="https://mastodon.social/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Alzheimer</span></a>’s, <a href="https://mastodon.social/tags/Parkinson" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Parkinson</span></a>’s and <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> diseases such as <a href="https://mastodon.social/tags/Creutzfeld" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Creutzfeld</span></a>-Jakob disease.<br><a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroscience</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2025/01/ns01062502.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2025/01/ns01062502.</span><span class="invisible">html</span></a></p>
Matt Willemsen<p>NIH Study Confirms: Humans Unlikely To Catch Deer Prion Disease<br><a href="https://scitechdaily.com/nih-study-confirms-humans-unlikely-to-catch-deer-prion-disease/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">scitechdaily.com/nih-study-con</span><span class="invisible">firms-humans-unlikely-to-catch-deer-prion-disease/</span></a> Health <a href="https://mastodon.social/tags/disease" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>disease</span></a> <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://mastodon.social/tags/deer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>deer</span></a> <a href="https://mastodon.social/tags/ChronicWasting" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ChronicWasting</span></a> <a href="https://mastodon.social/tags/cerebral" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cerebral</span></a> <a href="https://mastodon.social/tags/organoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>organoids</span></a> <a href="https://mastodon.social/tags/species" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>species</span></a> <a href="https://mastodon.social/tags/barrier" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>barrier</span></a></p>
Matt Willemsen<p>This New Clue May Signal Alzheimer's Before You Have Symptoms<br><a href="https://www.sciencealert.com/this-new-clue-may-signal-alzheimers-before-you-have-symptoms" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sciencealert.com/this-new-clue</span><span class="invisible">-may-signal-alzheimers-before-you-have-symptoms</span></a> <a href="https://mastodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>medicine</span></a> <a href="https://mastodon.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>alzheimers</span></a> <a href="https://mastodon.social/tags/biomarker" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biomarker</span></a> <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a></p>
Matt Willemsen<p>Two Hunters Died of Rare Prion Disease. Doctors Suspect a First-of-Its Kind Deer Transmission<br><a href="https://gizmodo.com/chronic-wasting-disease-deer-meat-prions-hunter-deaths-1851423216" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gizmodo.com/chronic-wasting-di</span><span class="invisible">sease-deer-meat-prions-hunter-deaths-1851423216</span></a> <a href="https://mastodon.social/tags/CWD" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CWD</span></a> <a href="https://mastodon.social/tags/deer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>deer</span></a> <a href="https://mastodon.social/tags/hunters" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hunters</span></a> <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://mastodon.social/tags/CJD" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CJD</span></a></p>
josh buermann<p>Bad news if you like venison but hate it when your brain turns into glue. <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://mastodon.social/tags/cwd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cwd</span></a></p><p><a href="https://www.neurology.org/doi/10.1212/WNL.0000000000204407" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">neurology.org/doi/10.1212/WNL.</span><span class="invisible">0000000000204407</span></a></p>
PLOS Biology<p>Orb2, the fly homolog of CPEB, forms <a href="https://fediscience.org/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a>-like oligomers involved in maintenance of <a href="https://fediscience.org/tags/LongTermMemory" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LongTermMemory</span></a>. This study identifies <a href="https://fediscience.org/tags/Hsp40" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hsp40</span></a> family chaperone Mrj as a regulator of <a href="https://fediscience.org/tags/Orb2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Orb2</span></a> oligomerization and its association with translating ribosomes <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/4aRba2j" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4aRba2j</span><span class="invisible"></span></a></p>
Matt Willemsen<p>Deer Are Beta-Testing a Nightmare Disease<br><a href="https://www.theatlantic.com/science/archive/2024/02/deer-chronic-wasting-disease-prions-spillover-people/677307/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">theatlantic.com/science/archiv</span><span class="invisible">e/2024/02/deer-chronic-wasting-disease-prions-spillover-people/677307/</span></a> <a href="https://mastodon.social/tags/deer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>deer</span></a> <a href="https://mastodon.social/tags/ChronicWastingDisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ChronicWastingDisease</span></a> <a href="https://mastodon.social/tags/CWD" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CWD</span></a> <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://mastodon.social/tags/MadCow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MadCow</span></a> <a href="https://mastodon.social/tags/fatal" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fatal</span></a> <a href="https://mastodon.social/tags/spreading" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>spreading</span></a> <a href="https://mastodon.social/tags/contagious" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>contagious</span></a> <a href="https://mastodon.social/tags/neurodegenerative" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neurodegenerative</span></a></p>
Brittany Trang<p>A possible clue in the hunt for what exactly causes Alzheimer's: It looks like Alzheimer's might be able to be transmitted.</p><p>Based on VERY rare cases of people who had, as children, received growth hormone taken from the brains of human cadavers and later developed early-onset Alzheimer's, it looks like ALZ might be related to prion diseases like Creutzfeldt-Jakob </p><p><a href="https://www.statnews.com/2024/01/29/first-transmitted-alzheimers-disease-cases-growth-hormone-cadavers/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">statnews.com/2024/01/29/first-</span><span class="invisible">transmitted-alzheimers-disease-cases-growth-hormone-cadavers/</span></a></p><p><a href="https://newsie.social/tags/alz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>alz</span></a> <a href="https://newsie.social/tags/AD" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AD</span></a> <a href="https://newsie.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>alzheimers</span></a> <a href="https://newsie.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://newsie.social/tags/dementia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dementia</span></a> <a href="https://newsie.social/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>health</span></a> <a href="https://newsie.social/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>medicine</span></a> <a href="https://newsie.social/tags/research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>research</span></a> <a href="https://newsie.social/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MedMastodon</span></a></p>
Matt Willemsen<p>An Incurable Disease Is Coming for Deer<br><a href="https://www.theatlantic.com/science/archive/2023/12/deer-chronic-wasting-disease-decline/676962/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">theatlantic.com/science/archiv</span><span class="invisible">e/2023/12/deer-chronic-wasting-disease-decline/676962/</span></a> <a href="https://mastodon.social/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>health</span></a> <a href="https://mastodon.social/tags/deer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>deer</span></a> <a href="https://mastodon.social/tags/elk" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>elk</span></a> <a href="https://mastodon.social/tags/moose" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>moose</span></a> <a href="https://mastodon.social/tags/ChronicWastingDisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ChronicWastingDisease</span></a> <a href="https://mastodon.social/tags/CWD" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CWD</span></a> <a href="https://mastodon.social/tags/incurable" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>incurable</span></a> <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> <a href="https://mastodon.social/tags/disease" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>disease</span></a></p>
Lorraine<p><a href="https://www.youtube.com/watch?v=TfE93xON8jk" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=TfE93xON8j</span><span class="invisible">k</span></a><br>Didn’t see this in 2013 <a href="https://zeroes.ca/tags/DebbieDowner" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DebbieDowner</span></a> <a href="https://zeroes.ca/tags/LindsayLohan" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LindsayLohan</span></a> clip but this is certifiably me. From the <a href="https://zeroes.ca/tags/madCow" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>madCow</span></a> <a href="https://zeroes.ca/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> disease I worried about showing up decades later circa 2000 to everyone fleeing her presence</p><p>I suppose it’s all of us <a href="https://zeroes.ca/tags/ZeroCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ZeroCovid</span></a> <a href="https://zeroes.ca/tags/noCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>noCovid</span></a> people now</p><p>Us against the world🤷🏻‍♀️</p>
FeralRobots<p><span class="h-card" translate="no"><a href="https://techhub.social/@hosford42" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>hosford42</span></a></span> <br>Model collapse as a <a href="https://mastodon.social/tags/prion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prion</span></a> disease. I like it (for values of 'I hate it').</p>
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