TMED9 mediates export of misfolded #prion proteins from the ER. This study shows that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @PLOSBiology https://plos.io/44kURu5

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for #prion disease that extends lifespan by about 50 percent in a mouse model of the fatal #neurodegenerative condition.
#Neuroscience #Genetics #sflorg
https://www.sflorg.com/2025/01/ns01142501.html

Protein aggregation is typical of various #neurodegenerative diseases such as #Alzheimer’s, #Parkinson’s and #prion diseases such as #Creutzfeld-Jakob disease.
#Neuroscience #sflorg
https://www.sflorg.com/2025/01/ns01062502.html

NIH Study Confirms: Humans Unlikely To Catch Deer Prion Disease
https://scitechdaily.com/nih-study-confirms-humans-unlikely-to-catch-deer-prion-disease/ Health #disease #prion #deer #ChronicWasting #cerebral #organoids #species #barrier

This New Clue May Signal Alzheimer's Before You Have Symptoms
https://www.sciencealert.com/this-new-clue-may-signal-alzheimers-before-you-have-symptoms #medicine #alzheimers #biomarker #prion

Two Hunters Died of Rare Prion Disease. Doctors Suspect a First-of-Its Kind Deer Transmission
https://gizmodo.com/chronic-wasting-disease-deer-meat-prions-hunter-deaths-1851423216 #CWD #deer #hunters #prion #CJD

Bad news if you like venison but hate it when your brain turns into glue. #prion #cwd

https://www.neurology.org/doi/10.1212/WNL.0000000000204407

Orb2, the fly homolog of CPEB, forms #prion-like oligomers involved in maintenance of #LongTermMemory. This study identifies #Hsp40 family chaperone Mrj as a regulator of #Orb2 oligomerization and its association with translating ribosomes #PLOSBiology https://plos.io/4aRba2j

Deer Are Beta-Testing a Nightmare Disease
https://www.theatlantic.com/science/archive/2024/02/deer-chronic-wasting-disease-prions-spillover-people/677307/ #deer #ChronicWastingDisease #CWD #prion #MadCow #fatal #spreading #contagious #neurodegenerative

A possible clue in the hunt for what exactly causes Alzheimer's: It looks like Alzheimer's might be able to be transmitted.

Based on VERY rare cases of people who had, as children, received growth hormone taken from the brains of human cadavers and later developed early-onset Alzheimer's, it looks like ALZ might be related to prion diseases like Creutzfeldt-Jakob

https://www.statnews.com/2024/01/29/first-transmitted-alzheimers-disease-cases-growth-hormone-cadavers/

An Incurable Disease Is Coming for Deer
https://www.theatlantic.com/science/archive/2023/12/deer-chronic-wasting-disease-decline/676962/ #health #deer #elk #moose #ChronicWastingDisease #CWD #incurable #prion #disease