JADe (he, him)<p><span class="h-card" translate="no"><a href="https://mastodon.social/@SteveThompson" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>SteveThompson</span></a></span> </p><p>Nice skeptic article as any true science should be. Anything that links the 2011 Russo paper "Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects" is to be celebrated. Here is the link again in case somebody missed it. </p><p><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">bpspubs.onlinelibrary.wiley.co</span><span class="invisible">m/doi/10.1111/j.1476-5381.2011.01238.x</span></a></p><p>Russo's paper has been cited 1,161 times and it deals with exogenous cannabinoids and terpenes synergy, not just endogenous o made inside our body, as did the original 1998 Mechoulam research.</p><p>Indeed, due to obsolete prohibitionism and sad profit-comes-first mentality, the current cannabis and hemp markets are a wild west of fake adultered product and unproven claims. </p><p>Yet since 2011 hundreds of studies have confirmed the entourage effect. Here is a small and incomplete collection of full spectrum extract papers 2004-2023.</p><p><a href="https://www.cvresearch.info/full-spectrum-hemp-extracts-studies" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cvresearch.info/full-spectrum-</span><span class="invisible">hemp-extracts-studies</span></a></p><p>OPs article calls for more standarized extract testing, even though Big Pharmas really prefers patentable, cheap to make, single molecule, symptom masking drugs. Good luck with that.</p><p>I agree with the article bottomline: governments should step up to the research task instead of trusting this critical matter to profit-driven corporations. Mixed isolate cannabis pharmaceuticals have been in the market for over a decade and proven their capabilities and limitations. </p><p>That is the case of Sativex, a 700 US$ 1:1 (thc:cbd) oral spray that controls some symptoms of MS yet fails to work for other conditions. Three separate studies ( Israeli, Brazilian and American) have since proven that full flower artisanal extracts are up to 6x more effective than expensive isolate preparations like Sativex<br><a href="https://sensiseeds-com.translate.goog/es/blog/sativex-el-pionero-de-los-farmacos-derivados-del-cannabis/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es-419&_x_tr_pto=wapp" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">sensiseeds-com.translate.goog/</span><span class="invisible">es/blog/sativex-el-pionero-de-los-farmacos-derivados-del-cannabis/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es-419&_x_tr_pto=wapp</span></a></p><p><a href="https://mastodon.cr/tags/Cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabis</span></a> <a href="https://mastodon.cr/tags/cannabismedicinal" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabismedicinal</span></a> <a href="https://mastodon.cr/tags/thc" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>thc</span></a> <a href="https://mastodon.cr/tags/thca" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>thca</span></a> <a href="https://mastodon.cr/tags/cbd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cbd</span></a> <a href="https://mastodon.cr/tags/cbda" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cbda</span></a> <a href="https://mastodon.cr/tags/entourageeffect" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>entourageeffect</span></a> <br><a href="https://mastodon.cr/tags/cannabislegal" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabislegal</span></a> <a href="https://mastodon.cr/tags/Cannabisgesetz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabisgesetz</span></a> <br><a href="https://mastodon.cr/tags/cannabislegalisierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabislegalisierung</span></a> <a href="https://mastodon.cr/tags/ganja" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ganja</span></a> <br><a href="https://mastodon.cr/tags/maconha" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>maconha</span></a> <a href="https://mastodon.cr/tags/weed" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>weed</span></a> <a href="https://mastodon.cr/tags/cannabisculture" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabisculture</span></a> <br><a href="https://mastodon.cr/tags/cannabisresearch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabisresearch</span></a> <a href="https://mastodon.cr/tags/chronicillness" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chronicillness</span></a> <br><a href="https://mastodon.cr/tags/ptsd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ptsd</span></a> <a href="https://mastodon.cr/tags/arthritis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>arthritis</span></a> <a href="https://mastodon.cr/tags/stress" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>stress</span></a> <a href="https://mastodon.cr/tags/depression" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>depression</span></a> <br><a href="https://mastodon.cr/tags/multiplesclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>multiplesclerosis</span></a> <a href="https://mastodon.cr/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ImmuneSystem</span></a></p>