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#breakthrough

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Tadonic the Flautulent

Baby Is Healed With World’s First Personalized Gene-Editing Treatment
The technique used on a 9½-month-old boy with a rare condition has the potential to help people with thousands of other uncommon genetic diseases.
nytimes.com/2025/05/15/health/
#news #science #breakthrough #genetics #GeneEditing

The New York Times · Baby Is Healed With World’s First Personalized Gene-Editing TreatmentBy Gina Kolata
Public
Francis Mangion (M)

(@)thebiomics [Instagram]: #downssyndrome #breakthrough instagram.com/p/DHYTjreuAuI/?i #forgoodorill

InstagramThe Biomics on Instagram: "BREAKING: Scientists Achieve Removal of Extra Chromosome in Down Syndrome! 🧬 Major milestone as researchers have used CRISPR-Cas9 gene-editing technology to remove the extra copy of chromosome 21 in human cells—marking a significant step forward in genetic research! How Was It Done? Scientists edited human stem cells derived from skin cells, precisely eliminating the extra chromosome responsible for trisomy 21 (Down syndrome)—all without disrupting the rest of the genome. This showcases the precision and potential of advanced genetic engineering. Why Is This Important? - This discovery reshapes our understanding of genetic conditions and their potential treatments. - While still in early stages, it paves the way for future therapies aimed at correcting genetic disorders at the cellular level. - It sparks a crucial question: Could gene editing one day prevent genetic conditions before birth? Although clinical applications are still far off, this breakthrough could revolutionize healthcare as we know it. PMID: 39967679 PMCID: PMC11832276 DOI: 10.1093/pnasnexus/pgaf022"9,715 likes, 104 comments - thebiomics on March 19, 2025: "BREAKING: Scientists Achieve Removal of Extra Chromosome in Down Syndrome! 🧬 Major milestone as researchers have used CRISPR-Cas9 gene-editing technology to remove the extra copy of chromosome 21 in human cells—marking a significant step forward in genetic research! How Was It Done? Scientists edited human stem cells derived from skin cells, precisely eliminating the extra chromosome responsible for trisomy 21 (Down syndrome)—all without disrupting the rest of the genome. This showcases the precision and potential of advanced genetic engineering. Why Is This Important? - This discovery reshapes our understanding of genetic conditions and their potential treatments. - While still in early stages, it paves the way for future therapies aimed at correcting genetic disorders at the cellular level. - It sparks a crucial question: Could gene editing one day prevent genetic conditions before birth? Although clinical applications are still far off, this breakthrough could revolutionize healthcare as we know it. PMID: 39967679 PMCID: PMC11832276 DOI: 10.1093/pnasnexus/pgaf022".
Public
Chuck Darwin

#Dennis #Gaitsgory has dedicated the past 30 years to proving the #geometric #Langlands #conjecture.
Over the decades, he and his collaborators have built an extensive body of work, forming the foundation of the new proof.
Although the geometric Langlands program is highly abstract, it forges deep connections between different mathematical structures
and has the potential to drive breakthroughs in theoretical physics, number theory, and even quantum computing.
The #Breakthrough #Prize was established in 2012 by Sergey Brin (Google), Mark Zuckerberg (Facebook), and others to recognize outstanding researchers for their groundbreaking discoveries.
It is awarded in the fields of life sciences, physics, and mathematics.
In 2016, the Breakthrough Prize in Life Sciences was awarded to #Svante #Pääbo from the Max Planck Institute for Evolutionary Anthropology in Leipzig,
and in 2022, to #Anthony #Hyman from the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden.
mpg.de/24476145/breakthrough-p

www.mpg.deDennis Gaitsgory wins 2025 Breakthrough Prize in mathematicsDennis Gaitsgory receives the 2025 Breakthrough Prize in Mathematics, endowed with 3 million US dollars “for foundational works and numerous breakthrough contributions to the geometric Langlands program and its quantum version; in particular, the development of the derived algebraic geometry approach and the proof of the geometric Langlands conjecture in characteristic 0”.
Public
Futurist Jim Carroll

"Whatever it takes. That has to be your mindset." - Futurist Jim Carroll

Many people seem to be engineered to give up too easily. Pack it in. Move on before the hard work. Never give what it takes. Abandon the effort. Never do what it takes.

The question is - why?

People seem to understand what success requires, yet consistently fail to take the necessary actions.

What's behind this attitude? 

Comfortable complacency. Too many get trapped in what I call the "good enough zone" - where they're just comfortable enough to resist real change, but not successful enough to thrive. This dangerous complacency is like a slow-acting poison in today's rapid-change environment.

A "not-my-problem' attitude. Too many people see the need for change but respond with "not my department" or "not my responsibility." This abandonment of responsibility creates a paradox: everyone sees the problem, but no one takes action.

Fear is the default setting. People are too scared to move and choose inaction as a strategy, mistaking it for prudence. But here's the reality: in 2025, the risk of doing nothing far outweighs the risk of action.

A lack of confidence. A lot of people have convinced themselves they can't adapt or master new realities. They've created their glass ceilings, limiting their potential before even trying.

Here's the stark reality: Success requires more than just knowing what to do - it demands the courage to do it. You need to move beyond understanding to action, beyond planning to execution, beyond fear to calculated risk-taking.

Here's the thought you need to plant in your mind - the future doesn't belong to the smartest or the strongest - it belongs to those willing to do whatever it takes to succeed.

So how do you do that?

Here's my list.

**#Persistence** **#Innovation** **#Growth** **#Action** **#Resilience** **#Speed** **#Commitment** **#Excellence** **#Fearless** **#Breakthrough**

Original post: jimcarroll.com/2025/02/daily-i

Public
Futurist Jim Carroll

"The time to escape mediocrity comes when you recognize the need to!" - Futurist Jim Carroll

I'm considering a sequel!

Should I?

With the impending release of the book about mediocrity, I've realized the perfect companion piece to it is an anti-mediocrity book!

Let's call it "Escaping Mediocrity: How to Accelerate Your Future and Achieve Breakthrough Results." That stands in nice contrast to the one due out in print any time now, "Embracing Mediocrity: How To Do Nothing Normal And Accomplish as Little as Possible."

It's the perfect combination!

After all, what's better than getting a new book? Getting two!

Even the cover image works - one fellow is burnt out, tired, and confused with his mediocre life. The other is vibrant, enthused, and eager with his mastery of creativity, innovation, and tomorrow!

I've even crafted together the back cover copy:

---

Finally, a book that provides the perfect antidote to a mediocre life!
In a world hungry for transformation, "Escaping Mediocrity" illuminates the path from ordinary to extraordinary. This dynamic guide maps the territory between settling and soaring, revealing the precise moments where breakthrough decisions launch everyday people into a remarkable achievement.

Through 125 research-backed strategies and real-world success stories, readers will discover how small, intentional choices compound into monumental results. It's a practical playbook for anyone ready to trade comfortable plateaus for the exhilarating climb toward their full potential.

Whether you're reinventing your career, scaling an organization, or pursuing audacious personal goals, this comprehensive guide delivers a masterclass in identifying and seizing the pivotal moments that separate the exceptional from the average.

You'll uncover the science of breakthrough performance and the actionable steps that turn distant dreams into daily progress.

After all, why hug the ground when the stars are within reach? This isn't just a roadmap to excellence – it's your launch pad to a life of extraordinary impact!

----

What do you think?

Should I go for it?

**#Mediocrity** **#Growth** **#Success** **#Achievement** **#Excellence** **#Progress** **#Transformation** **#Initiative** **#Action** **#Breakthrough**

Original post: jimcarroll.com/2025/02/daily-i

Public
50+ Music

"Fallin' for You" is a song by American singer-songwriter #ColbieCaillat. It was written by Caillat along with #RickNowels and produced by Nowels, #JohnShanks, and Caillat's father, #KenCaillat, for her second studio album, #Breakthrough (2009). The song was released on June 26, 2009, as the lead single from the album, through #UniversalRepublic. According to Caillat, the song speaks of someone falling for a man that they are friends with.
youtube.com/watch?v=SycVgytRTQ4

YouTubeFallin' For YouBy Colbie Caillat - Topic
Public
PhoenixSerenity

#ChineseScientists successfully #transplanted the liver of #GeneEdited #pig into a 71 yr old male patient with giant right lobe #LiverCancer. The patient is moving freely without acute or hyperacute rejection reactions 7 days post surgery.

#WorldsFirst #liver #xenotransplantation #surgery of a living human. China's xenotransplantation #technology has reached a significant #breakthrough in the #medical field - #FirstAffiliatedHospital of #AnhuiMedicalUniversity.

globaltimes.cn/page/202405/131

www.globaltimes.cnChinese scientists conduct world's first liver xenotransplantation surgery for human successfully - Global Times
Public
kurtsh

This vaccine development technique works on babies with under-developed immunity or immunocompromised individuals because it doesn't rely on the person's own immune system. And it can work for any virus.

"This could be the universal vaccine that we have been looking for.”

DUDE.

Vaccine breakthrough means no more chasing strains | UCR News | UC Riverside
news.ucr.edu/articles/2024/04/

NewsVaccine breakthrough means no more chasing strainsScientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.
#vaccines#ucr#breakthrough
Public
Tom Maxwell

“The winners of a contest called the Vesuvius Challenge trained their machine-learning algorithms on scans of the rolled-up papyrus, unveiling a previously unknown philosophical work that discusses senses and pleasure. The feat paves the way for artificial intelligence (AI) techniques to decipher the rest of the scrolls in their entirety, which researchers say could have revolutionary implications for our understanding of the ancient world.”
#Archeological #breakthrough
nature.com/articles/d41586-024

www.nature.comFirst passages of rolled-up Herculaneum scroll revealedResearchers used artificial intelligence to decipher the text of 2,000-year-old charred papyrus scripts, unveiling musings on music and capers.
Public
Hari Tulsidas

U.S. government scientists have achieved net energy gain in a fusion reaction for the second time since December last year. They repeated the breakthrough in an experiment on July 30 that produced a higher energy output than in December. This could be a game-changer for climate and energy, as fusion has the potential to offer nearly limitless, carbon-free energy and displace fossil fuels and other traditional energy sources. #FusionEnergy #Breakthrough #ClimateChange reuters.com/business/energy/us

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