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#Tcells

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@Co_Biologists<p>📢 Call for speakers</p><p>We are looking for early-career researchers to speak in FocalPlane's mini-symposium run together with the popular membrane trafficking webinar series organised by Francesca Bottanelli, Fèlix Campelo and Ishier Raote.</p><p>Application deadline: Sunday 24 August</p><p>Find out more:</p><p><a href="https://focalplane.biologists.com/2025/07/14/focalplane-features-membrane-trafficking-apply-to-give-a-talk/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">focalplane.biologists.com/2025</span><span class="invisible">/07/14/focalplane-features-membrane-trafficking-apply-to-give-a-talk/</span></a></p><p><a href="https://biologists.social/tags/FocalPlaneFeatures" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FocalPlaneFeatures</span></a> <a href="https://biologists.social/tags/Microscopy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Microscopy</span></a> <a href="https://biologists.social/tags/MembraneTrafficking" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MembraneTrafficking</span></a> <a href="https://biologists.social/tags/Cells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cells</span></a> <a href="https://biologists.social/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a> <a href="https://biologists.social/tags/ECR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ECR</span></a> <a href="https://biologists.social/tags/ImmunologicalSynapse" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ImmunologicalSynapse</span></a> <a href="https://biologists.social/tags/MembraneDynamics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MembraneDynamics</span></a> <a href="https://biologists.social/tags/Microscope" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Microscope</span></a> <a href="https://biologists.social/tags/CellBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CellBiology</span></a></p>
datum (n=1)<blockquote><p>Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin</p></blockquote><p><a href="https://www.healthrising.org/wp-content/uploads/2025/05/Perforin_Selin_Webinar_25.gif" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">healthrising.org/wp-content/up</span><span class="invisible">loads/2025/05/Perforin_Selin_Webinar_25.gif</span></a></p><p>[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]</p><p>they also found</p><blockquote><p>a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.</p><p>Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.</p></blockquote><p>which compensates in part for the lower perforin, but also led to</p><blockquote><p>a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.</p></blockquote><p>from <a href="https://www.healthrising.org/blog/2025/05/15/t-cell-exhaustion-chronic-fatigue-long-covid/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">healthrising.org/blog/2025/05/</span><span class="invisible">15/t-cell-exhaustion-chronic-fatigue-long-covid/</span></a></p><p><a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/MECFS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MECFS</span></a> <a href="https://zeroes.ca/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LongCOVID</span></a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CovidIsNotOver</span></a> <a href="https://zeroes.ca/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a> <a href="https://zeroes.ca/tags/NKCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NKCells</span></a> <a href="https://zeroes.ca/tags/CD8" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CD8</span></a> <a href="https://zeroes.ca/tags/CD4" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CD4</span></a></p>
PLOS Biology<p>Regulatory <a href="https://fediscience.org/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> (Tregs) exist in distinct subsets, but how is this regulated? Saxena &amp; He explore a recent <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>PLOSBiology</span></a></span> study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector <a href="https://fediscience.org/tags/Treg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Treg</span></a> generation &amp; maintenance. Paper: <a href="https://plos.io/42xmddU" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/42xmddU</span><span class="invisible"></span></a> Primer: <a href="https://plos.io/4lz0hYA" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4lz0hYA</span><span class="invisible"></span></a></p>
halama_immuno<p>Immunotherapy of Camcer <a href="https://mstdn.science/tags/ITOC11" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ITOC11</span></a> conference started with a packed program and auditorium. Plenty of topics from immunobiology to clinical experimental immunotherapies. See www.itoc-conferences.eu<br><a href="https://mstdn.science/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunotherapy</span></a> <a href="https://mstdn.science/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>science</span></a> <a href="https://mstdn.science/tags/Immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Immunology</span></a> <a href="https://mstdn.science/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>medicine</span></a> <a href="https://mstdn.science/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a> <a href="https://mstdn.science/tags/tcellreceptors" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tcellreceptors</span></a> <a href="https://mstdn.science/tags/cellulartherapies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cellulartherapies</span></a> <a href="https://mstdn.science/tags/macrophages" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>macrophages</span></a> <a href="https://mstdn.science/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>health</span></a></p>
Matt Willemsen<p>Surprise Discovery: Scientists Discover New Anti-Cancer Potential of Salt<br><a href="https://scitechdaily.com/surprise-discovery-scientists-discover-new-anti-cancer-potential-of-salt/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">scitechdaily.com/surprise-disc</span><span class="invisible">overy-scientists-discover-new-anti-cancer-potential-of-salt/</span></a> <a href="https://mastodon.social/tags/salt" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>salt</span></a> <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancer</span></a> <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> <a href="https://mastodon.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Immunology</span></a></p>
PLOS Biology<p>Quality &amp; longevity of CD4+ <a href="https://fediscience.org/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> change with age in mice. @AYatesGroup &amp;co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/46PBjgX" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/46PBjgX</span><span class="invisible"></span></a></p>
Mast0b1t<p><span class="h-card" translate="no"><a href="https://norden.social/@kraweel65" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>kraweel65</span></a></span> <span class="h-card" translate="no"><a href="https://urbanists.social/@TransitBiker" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>TransitBiker</span></a></span> </p><p><a href="https://www.merckmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">merckmanuals.com/professional/</span><span class="invisible">hematology-and-oncology/leukopenias/lymphocytopenia</span></a></p><p>Uli, <a href="https://awscommunity.social/tags/SarsCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SarsCoV2</span></a> permanently kills off <a href="https://awscommunity.social/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a>. With one or repeat infections, you can get <a href="https://awscommunity.social/tags/LongCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LongCovid</span></a> as a result. By then, you are open to opportunistic infections.</p><p>Clean your indoor air with HEPA filters or a <a href="https://awscommunity.social/tags/CorsiRosenthalBox" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CorsiRosenthalBox</span></a>. Wear <a href="https://awscommunity.social/tags/N95" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>N95</span></a> respirators or better. 😷</p><p>Also see: <span class="h-card" translate="no"><a href="https://bird.makeup/users/dbdugger" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>dbdugger</span></a></span></p>
Monika Wolkers<p>Please find below our most recent pre-print. We studied the role of the RNA binding protein ZFP36L2 in effector T cells and found how it regulated the production of IFNgamma in late T cell responses and continuous activation with tumor cells (in vitro/in vivo). Happy reading!</p><p><a href="https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.02.09.579641v1.article-metrics</span></a></p><p><a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunology</span></a> <a href="https://mstdn.science/tags/tumor" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tumor</span></a> <a href="https://mstdn.science/tags/rna_binding_proteins" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>rna_binding_proteins</span></a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cytokines</span></a></p>
PLOS Biology<p>&gt;90% of <a href="https://fediscience.org/tags/TCR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCR</span></a> sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity <a href="https://fediscience.org/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> generated by TdT are important for curtailing chronic pathogen replication <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3HJKOCl" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3HJKOCl</span><span class="invisible"></span></a></p>
Lorraine<p>The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know &amp; they come at them with <a href="https://zeroes.ca/tags/CovidPapers" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CovidPapers</span></a> <a href="https://zeroes.ca/tags/Jha" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Jha</span></a></p><p>This will be my continuing🧵on anything related to the destruction of <a href="https://zeroes.ca/tags/tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tcells</span></a> <a href="https://zeroes.ca/tags/bcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bcells</span></a> <a href="https://zeroes.ca/tags/ImmuneDysregulation" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ImmuneDysregulation</span></a> in an attempt to be organized if only for myself🖤</p><p>Published January 14, 2022<br><a href="https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02228-6" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">bmcmedicine.biomedcentral.com/</span><span class="invisible">articles/10.1186/s12916-021-02228-6</span></a></p><p>In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my <a href="https://zeroes.ca/tags/sarscov2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sarscov2</span></a> 2nd infection b/c my level of biology was zero &amp; my lack of understanding led me to believe <a href="https://zeroes.ca/tags/hybridImmunity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hybridImmunity</span></a> would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021</p><p>Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&amp;🐦have been invaluable in at least allowing me to read &amp; generally follow along</p><p>Basically this study tells me, stay down for 6 months minimum</p>
Lorraine<p>On a totally unrelated note🙄<br><a href="https://www.youtube.com/watch?v=BlQOgs9fzc4" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=BlQOgs9fzc</span><span class="invisible">4</span></a></p><p>I know :deadbirb: :twitterfire: is bad, but I do love <br>sue @🖤 inkblue01 who has the best info<br><a href="https://zeroes.ca/tags/tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tcells</span></a> <a href="https://zeroes.ca/tags/bcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>bcells</span></a> <a href="https://zeroes.ca/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancer</span></a></p>
Auscandoc<p>“By analyzing a longitudinal cohort of individuals infected with <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARSCoV2</span></a> during the first wave of <a href="https://med-mastodon.com/tags/pandemic" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>pandemic</span></a> infections, Cai et al. found that subsequent <a href="https://med-mastodon.com/tags/vaccination" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccination</span></a> against <a href="https://med-mastodon.com/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID19</span></a> enhanced the frequency and functional qualities of <a href="https://med-mastodon.com/tags/spike" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>spike</span></a>-specific <a href="https://med-mastodon.com/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a>. Despite up-regulation of inhibitory receptors, spike-specific T cells produced more effector <a href="https://med-mastodon.com/tags/cytokines" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cytokines</span></a> and cytotoxic molecules after <a href="https://med-mastodon.com/tags/vaccination" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccination</span></a>” <a href="https://mstdn.social/@erictopol/111546489766413387" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">mstdn.social/@erictopol/111546</span><span class="invisible">489766413387</span></a></p>
Scientific Frontline<p>Most T cells only work in the person who made them. Your T cells fight threats by responding to <a href="https://mastodon.social/tags/molecular" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>molecular</span></a> fragments that belong to a <a href="https://mastodon.social/tags/pathogen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>pathogen</span></a>—but only when these <a href="https://mastodon.social/tags/molecules" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>molecules</span></a> are bound with markers that come from your own tissues. <br><a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Biology</span></a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medical</span></a> <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2023/11/bio11122301.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2023/11/bio11122301</span><span class="invisible">.html</span></a></p>
Auscandoc<p>“Here, we asked whether <a href="https://med-mastodon.com/tags/mRNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mRNA</span></a> <a href="https://med-mastodon.com/tags/vaccine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccine</span></a>-induced memory <a href="https://med-mastodon.com/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> limits lung <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARSCoV2</span></a> replication and severe disease. We show that mice and humans receiving booster BioNTech mRNA vaccine developed potent <a href="https://med-mastodon.com/tags/CD8" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CD8</span></a> T-cell responses” <a href="https://med-mastodon.com/@rchusid/111369486860202910" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">med-mastodon.com/@rchusid/1113</span><span class="invisible">69486860202910</span></a></p>
Alan Kotok<p>Electric Pulses Induce Lung Cancer Immune Response</p><p>Results of a clinical trial show a lung cancer therapy using highly focused pulses with electrical energy show signs of immune responses that can treat the patients' tumors.</p><p><a href="https://sciencebusiness.technewslit.com/?p=45375" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">sciencebusiness.technewslit.co</span><span class="invisible">m/?p=45375</span></a></p><p><a href="https://journa.host/tags/News" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>News</span></a> <a href="https://journa.host/tags/Press" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Press</span></a> <a href="https://journa.host/tags/Science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Science</span></a> <a href="https://journa.host/tags/Business" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Business</span></a> <a href="https://journa.host/tags/Cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cancer</span></a> <a href="https://journa.host/tags/LungCancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LungCancer</span></a> <a href="https://journa.host/tags/Therapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Therapy</span></a> <a href="https://journa.host/tags/ElectricField" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ElectricField</span></a> <a href="https://journa.host/tags/ClinicalTrial" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ClinicalTrial</span></a> <a href="https://journa.host/tags/Resection" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Resection</span></a> <a href="https://journa.host/tags/Surgery" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Surgery</span></a> <a href="https://journa.host/tags/Ablation" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Ablation</span></a> <a href="https://journa.host/tags/MedicalDevice" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MedicalDevice</span></a> <a href="https://journa.host/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ImmuneSystem</span></a> <a href="https://journa.host/tags/BCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BCells</span></a> <a href="https://journa.host/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a></p>
Scientific Frontline<p>Our <a href="https://mastodon.social/tags/immune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immune</span></a> system’s T cells kill <a href="https://mastodon.social/tags/tumors" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tumors</span></a> and virus-infected cells to prevent disease from spreading to healthy tissues. However, in order to recognize their target and perform their protective function, T cells must undergo a process of maturation<br><a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> <a href="https://mastodon.social/tags/Virus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Virus</span></a> <a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Biology</span></a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medical</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2023/10/bio10262303.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2023/10/bio10262303</span><span class="invisible">.html</span></a></p>
Alan Kotok<p>A company with a process to generate new thymus tissue for immune system functions is receiving a $37 million award from the government's health breakthrough agency. </p><p><a href="https://sciencebusiness.technewslit.com/?p=45277" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">sciencebusiness.technewslit.co</span><span class="invisible">m/?p=45277</span></a> </p><p><a href="https://journa.host/tags/News" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>News</span></a> <a href="https://journa.host/tags/Press" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Press</span></a> <a href="https://journa.host/tags/Science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Science</span></a> <a href="https://journa.host/tags/Business" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Business</span></a> <a href="https://journa.host/tags/Thymus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Thymus</span></a> <a href="https://journa.host/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ImmuneSystem</span></a> <a href="https://journa.host/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a> <a href="https://journa.host/tags/ARPAH" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ARPAH</span></a> <a href="https://journa.host/tags/Biotechnology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Biotechnology</span></a> <a href="https://journa.host/tags/StemCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>StemCells</span></a> <a href="https://journa.host/tags/TissueEngineering" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TissueEngineering</span></a> <a href="https://journa.host/tags/MachineLearning" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MachineLearning</span></a> <a href="https://journa.host/tags/ArtificialIntelligence" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ArtificialIntelligence</span></a> <a href="https://journa.host/tags/Algorithms" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Algorithms</span></a></p>
cgp<p>'The question was – what was happening to the <a href="https://techhub.social/tags/TCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TCells</span></a> over 2 years in<br><a href="https://techhub.social/tags/LongCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LongCovid</span></a> and recovered <a href="https://techhub.social/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID</span></a> patients? Theoretically, the T-cells should have ramped up to knock down the virus, and once they did that, quieted down – but that’s not what happened at all – not even in the recovered group.</p><p>'Even in the recovered group, the T-cells remained abnormally activated in a whole slew of tissues – the brain stem, spinal cord, bone marrow, nasopharyngeal and hilar lymphoid tissue, cardiopulmonary vasculature, lung parenchyma, and gut wall. Finding so much remaining T-cell activation in the recovered patients suggested that the coronavirus infection had resulted in “a new immunologic steady state”.</p><p>'The T-cells could still be trying to cleanse the body of the coronavirus or they could reflect an autoimmune response. Whatever is happening it’s clear that infections – even infections that seem to have been fought off – have consequences.'</p>
Monika Wolkers<p><a href="https://www.biorxiv.org/content/10.1101/2023.09.03.556079v1" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.09.03.556079v1</span></a></p><p><a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Tcells</span></a> <a href="https://mstdn.science/tags/HLA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HLA</span></a> <a href="https://mstdn.science/tags/Antigen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Antigen</span></a> <a href="https://mstdn.science/tags/ML" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ML</span></a> <a href="https://mstdn.science/tags/prediction" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>prediction</span></a></p>
IT News<p>T cells burn out just a few hours after encountering cancer tumors - Enlarge / This microscopy image shows a cytotoxic T cell (blue) attacki... - <a href="https://arstechnica.com/?p=1959111" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">arstechnica.com/?p=1959111</span><span class="invisible"></span></a> <a href="https://schleuss.online/tags/immuneresponse" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immuneresponse</span></a> <a href="https://schleuss.online/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunotherapy</span></a> <a href="https://schleuss.online/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>science</span></a> <a href="https://schleuss.online/tags/t" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>t</span></a>-ceels <a href="https://schleuss.online/tags/health" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>health</span></a> <a href="https://schleuss.online/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancer</span></a> <a href="https://schleuss.online/tags/tcells" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tcells</span></a></p>