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#innateimmune

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PLOS Biology<p>Innate immune signaling and <a href="https://fediscience.org/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancer</span></a>: This study shows that the tissue-protective functions of Toll-mediated <a href="https://fediscience.org/tags/InnateImmune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>InnateImmune</span></a> signaling can be misused by premalignant cells in <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Drosophila</span></a> to induce overgrowth in early stages of <a href="https://fediscience.org/tags/tumor" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tumor</span></a> development <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>PLOSBiology</span></a></span> <a href="https://plos.io/4jqpmUh" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4jqpmUh</span><span class="invisible"></span></a></p>
PLOS Biology<p><a href="https://fediscience.org/tags/ProteinQC" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ProteinQC</span></a> pathways play key roles in resistance to <a href="https://fediscience.org/tags/pathogens" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>pathogens</span></a>. @manishgrover_4 @barkoulab &amp;co show that <a href="https://fediscience.org/tags/proteasome" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>proteasome</span></a> regulation keeps <a href="https://fediscience.org/tags/InnateImmune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>InnateImmune</span></a> responses against natural pathogens of <a href="https://fediscience.org/tags/Celegans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Celegans</span></a> in check in a tissue-specific manner <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3PhIjLW" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3PhIjLW</span><span class="invisible"></span></a></p>
PLOS Biology<p>How did our <a href="https://fediscience.org/tags/InnateImmune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>InnateImmune</span></a> systems first evolve? Ed Culbertson &amp; @tera_levin reveal origins of three families of <a href="https://fediscience.org/tags/antiviral" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antiviral</span></a> proteins: CD-NTases (incl <a href="https://fediscience.org/tags/cGAS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cGAS</span></a>), STINGs &amp; <a href="https://fediscience.org/tags/Viperins" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Viperins</span></a>; each reveals a different story connecting animal &amp; bacterial immunity <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/46SfBqM" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">plos.io/46SfBqM</span><span class="invisible"></span></a></p>
PLOS Biology<p>The <a href="https://fediscience.org/tags/GPCR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>GPCR</span></a> CMKLR1 responds to the <a href="https://fediscience.org/tags/adipokine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>adipokine</span></a> <a href="https://fediscience.org/tags/chemerin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chemerin</span></a> and is abundant in <a href="https://fediscience.org/tags/InnateImmune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>InnateImmune</span></a> cells. Structure of CMKLR1 in complex with <a href="https://fediscience.org/tags/Gprotein" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gprotein</span></a> and a peptide agonist (+ mutagenesis &amp; simulations) reveals mechanisms of action <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/4a6Igvd" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">plos.io/4a6Igvd</span><span class="invisible"></span></a></p>
PLOS Biology<p>The past 20 years have revealed several new <a href="https://fediscience.org/tags/InnateImmune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>InnateImmune</span></a> sensing &amp; <a href="https://fediscience.org/tags/CellDeath" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CellDeath</span></a> pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries &amp; forwards toward their future therapeutic potential <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/40O9xxQ" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="">plos.io/40O9xxQ</span><span class="invisible"></span></a></p>
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