Shakedown Social

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Robert MasseyPrep mostly done. So it's stage 1 of checking out how to deal with ongoing (37 years) Crohn's and diverticulitis disease tomorrow. First up is a colonoscopy, which always fascinates the scientist in me if nothing else. <a href="https://astrodon.social/tags/Crohns" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Crohns</a> <a href="https://astrodon.social/tags/Colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Colitis</a> <a href="https://astrodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicine</a>

DoomsdaysCW<a href="https://kolektiva.social/tags/Cannabinoids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cannabinoids</a> as novel <a href="https://kolektiva.social/tags/AntiInflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AntiInflammatory</a> drugsby Prakash Nagarkatti, et al. October, 2009Abstract:"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (<a href="https://kolektiva.social/tags/THC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#THC</a>) as the major psychoactive principle in marijuana, as well as the identification of <a href="https://kolektiva.social/tags/cannabinoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cannabinoid</a> receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on <a href="https://kolektiva.social/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immune</a> cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate <a href="https://kolektiva.social/tags/cytokine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokine</a> and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress <a href="https://kolektiva.social/tags/inflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammatory</a> responses. The <a href="https://kolektiva.social/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#endocannabinoid</a> system is also involved in <a href="https://kolektiva.social/tags/immunoregulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunoregulation</a>. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."Executive summary- Cannabinoids, the active components of <a href="https://kolektiva.social/tags/CannabisSativa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CannabisSativa</a>, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.- Cannabinoids have been tested in several experimental models of autoimmune disorders such as <a href="https://kolektiva.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MultipleSclerosis</a>, <a href="https://kolektiva.social/tags/RheumatoidArthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RheumatoidArthritis</a>, <a href="https://kolektiva.social/tags/colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#colitis</a> and <a href="https://kolektiva.social/tags/hepatitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hepatitis</a> and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.- Cannabinoids may also be beneficial in certain types of <a href="https://kolektiva.social/tags/cancers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancers</a> that are triggered by <a href="https://kolektiva.social/tags/ChronicInflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ChronicInflammation</a> In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/</a>

Scientific FrontlineIt’s a hidden cause of <a href="https://mastodon.social/tags/diarrhea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diarrhea</a> and the development of the disease is poorly understood. Multiple factors work against the diagnosis of <a href="https://mastodon.social/tags/microscopic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microscopic</a> <a href="https://mastodon.social/tags/colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#colitis</a>, an inflammatory <a href="https://mastodon.social/tags/digestive" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#digestive</a> disease <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2023/12/med12132305.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2023/12/med12132305.html</a>

Scientific FrontlineTreatment of the chronic inflammatory bowel disease <a href="https://mastodon.social/tags/ulcerative" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ulcerative</a> <a href="https://mastodon.social/tags/colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#colitis</a> often produces unsatisfactory results. Researchers at the University of Bern have now developed a lipid gel that is administered directly to the inflamed part of the <a href="https://mastodon.social/tags/intestine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#intestine</a> <a href="https://mastodon.social/tags/Chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Chemistry</a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/Pharmaceutical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pharmaceutical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2023/10/chm10242301.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2023/10/chm10242301.html</a>

Ismael ReyesEn lo personal diría que lo más importante de mí es que soy <a href="https://masto.kix2902.dev/tags/bisiesto" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bisiesto</a> (los números de mi nick son por eso), <a href="https://masto.kix2902.dev/tags/dalt%C3%B3nico" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#daltónico</a> (concretamente tengo <a href="https://masto.kix2902.dev/tags/deuteranomal%C3%ADa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#deuteranomalía</a>) y <a href="https://masto.kix2902.dev/tags/gallego" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gallego</a> (más exactamente de <a href="https://masto.kix2902.dev/tags/Vigo" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Vigo</a>).En cuanto a las cosas menos guays, tengo una minusvalía física del 33% (estoy esperando una revisión) por <a href="https://masto.kix2902.dev/tags/EspondilitisAnquilosante" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EspondilitisAnquilosante</a> (diagnosticada en 2008) y <a href="https://masto.kix2902.dev/tags/Colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Colitis</a> (diagnosticada en 2019)... También pasé por una <a href="https://masto.kix2902.dev/tags/Tuberculosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tuberculosis</a> en 2014.Me defino como <a href="https://masto.kix2902.dev/tags/geek" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#geek</a>, <a href="https://masto.kix2902.dev/tags/esc%C3%A9ptico" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#escéptico</a>, <a href="https://masto.kix2902.dev/tags/GoogleFan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GoogleFan</a> y <a href="https://masto.kix2902.dev/tags/EarlyAdopter" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EarlyAdopter</a>.

Simon MooijaartProud of the impressive <a href="https://mastodon.green/tags/thesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#thesis</a> by the talented Vera Asscher: <a href="https://mastodon.green/tags/Inflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Inflammatory</a> <a href="https://mastodon.green/tags/Bowel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bowel</a> <a href="https://mastodon.green/tags/Disease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Disease</a>; from gut feeling towards evidence-based <a href="https://mastodon.green/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicine</a>Looking farward to the defence on June 6th 🥳 <a href="https://mastodon.green/tags/geriatrics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#geriatrics</a> <a href="https://mastodon.green/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MedMastodon</a> <a href="https://mastodon.green/tags/IBD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IBD</a> <a href="https://mastodon.green/tags/crohn" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#crohn</a> <a href="https://mastodon.green/tags/colitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#colitis</a>

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